Pharmaceutical Analysis

Separation Science Solutions Series

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Detection in Capillary Electrophoresis (CE)

This article discusses the most popular detection principles in use in industry and CE-related good working practice.

Injection Precision and Sensitivity in Capillary Electrophoresis (CE)

We discussed the significance of a constant electro-osmotic flow and good capillary conditioning for precision in our CE methods. Now we look at the importance of injection settings for precision. We will also have a first look at sample stacking...

Capillary Conditioning — The Foundation of Precision in capillary electrophoresis (CE)

In previous issues, we saw the importance of a controlled, constant electro-osmotic flow (EOF) for proper precision. In this issue, we will therefore look into the different strategies for capillary conditioning, as a good conditioning procedure is...

The Capillary Electrophoresis (CE) Capillary

The small diameter of the capillary in capillary electrophoresis makes for very good heat dissipation compared with conventional electrophoresis. As a consequence, much higher voltages can be applied before heat dissipation becomes an issue. 

Method Development in Capillary Electrophoresis (CE): Selecting your Background Electrolyte

The selection of the proper background electrolyte (BGE) is key to a successful CE method. We first look into the choices for BGE based on our analyte properties. Capillary electrophoresis (CE) is based on migration of charged components in an...

Reaction Monitoring with UltraPerformance Convergence Chromatography

Once a chemical hit is found through a library screening process and verified, the synthetic route is then optimized. This step involves an iterative process of synthesis and reactivity measurements of the new compound(s) to further develop the drug...

Why CE (Capillary Electrophoresis)?

The capillary electrophoresis (CE)techniques have been around since the 1980s, and commercial instruments available since the end of that decade. So why would we start on such a topic now? There are several indications for a growing interest in CE...

Practical Considerations for Achiral Analysis of Pharmaceutical Compounds Using Convergence Chromatography

In convergence chromatography (CC), the modes of interaction between the stationary phase and the solute are numerous, including hydrogen bonding, hydrophobic interactions, dipolar and polarizability interactions and solute partitioning [1]. These...

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