This study describes the LCMS bioanalysis of antibody drugs using the Fab-selective proteolysis "nSMOL Method" offering an improvement of reaction conditions for automated analyses.
PSS has produced an application note demonstrating a specific workflow in which its PSS WinGPC Software allows for calibration and molar mass determination for Dextran 40, 60 and 70 as stated by United States Pharmacopeia (USP) and European...
Metrohm has produced an application note describing the straightforward determination of acid-neutralizing capacity (ANC) for numerous over-the-counter (OTC) antacids.
This useful compendium from Thermo Fisher provides detailed methods for the analysis of trace elements in pharmaceutical products using AAS, ICP-OES and ICP-MS covered by the NEW USP chapters 232 and 233.
Thermo Fisher Scientific has produced an application note describing a novel Dual LC workflow, which provides a unique concept by using two separated flow paths in one system. It shows how the Thermo Scientific Vanquish Duo system for Dual LC...
Kromasil has produced an application note demonstrating how, by using merged inorganic/organic silica materials with newly developed C8, C18 or phenyl hexyl phases, it is possible to use a stationary phase with a wider pH range.
SCIEX has produced an application note demonstrating how to monitor biotherapeutic oxidation levels in a simple and automated way using the X500B QTOF system and powerful BioPharmaView™ Software.
SCIEX has produced an application note demonstrating using a reproducible and robust method for analysing intact biotherapeutic proteins on the X500B QTOF System with automated batch processing using BioPharmaView™ software.
SCIEX has produced an application note describing a simple and rapid methodology to characterize and quantify differences between biotherapeutic batches, using high-resolution peptide mapping by LC-MS.
Agilent Technologies has produced an application note demonstrating the use of high-resolution (HiRes) sampling 2D-LC for the separation and detection of impurities, exemplified for different isomers of chlorodifluorobenzoic acid at relative...
SCIEX has produced an application note describing the N-glycosylation profiling of carbohydrates associated with therapeutic antibodies for faster, more cost-effective development of biologics.
Shimadzu has produced an application note describing phospholipid analysis for four types of mouse tissues performed by precursor ion scan (PIS) or neutral loss scan (NLS) with a triple quadrupole mass spectrometer.