Pharmaceutical Analysis

In this application note purification of a single-stranded RNA oligonucleotide by ion pair reversed-phase HPLC is demonstrated, achieving > 99% pure fraction pool with a yield of > 56%.

Separation Science, in collaboration with Shimadzu, offers a series of application notes covering everything from a high efficiency workflow for simple fractionation, examples of preparative purification and comprehensive fractionation of herbal...

Separation Science, in collaboration with Shimadzu, offers a series of application notes describing the quantitation of various nitrosamines in drugs and solvents using its LC/MS or GC/MS instruments. Click below to download your personal copies.

Separation Science, in collaboration with Shimadzu, offers a series of application notes exploring the latest and most up-to-date solutions for COVID-19 drug analysis. Click below to download your personal copies.

Separation Science, in collaboration with SepSolve Analytical, offers a selection of application notes relevant for pharma and clinical analysis embracing sample extraction and enrichment with comprehensive two-dimensional GC (GC×GC) technologies.

Separation Science, in collaboration with Agilent, offers an eBook containing a selection of application notes relevant for pharmaceutical and clinical analysis using gas chromatography (GC). Discover an effective method for the analysis of USP<467>...

Separation Science, in collaboration with Agilent, offers an eBook covering new and advanced methods, applications and case studies in automated sample preparation workflows.

Separation Science, in collaboration with Thermo Fisher Scientific, offers a selection of application notes relevant for biopharmaceutical analysis. Discover the latest advances in high-resolution accurate-mass (HRAM) mass spectrometry. Learn more...

Tosoh Bioscience has produced Volume 1 of its 'Bioprocessing Application Notebook' that comprises over twenty application notes covering important aspects of biopharmaceutical purification.

Are you looking for solutions to your biopharmaceutical workflows? Struggling with your intact protein analysis, or need help with glycosylation studies? If so Separation Science, in collaboration with Thermo Fisher Scientific, has developed an...

This application from Agilent describes the 2D-LC analysis of complex peptones. Active solvent modulation proved to be valuable to maintain chromatographic performance and avoid breakthrough in the second dimension.

Recently, the evolution of middle to large biomacromolecules such as peptides or proteins is apparent in the market of pharmaceutical drugs in addition to traditional active ingredients based on small molecules. The use of peptides for clinical...

The aim of this study was to develop a rapid, cost-effective, modified USP <467> HS-GC-FID method for residual solvent determination in pharmaceutical products using the Thermo Scientific™ TriPlus™ 500 Headspace Autosampler and nitrogen as carrier...

This application note provides an evaluation of the quantitative performance of the Thermo Scientific™ TriPlus™ 500 Gas Chromatography Headspace Autosampler for determination of genotoxic nitrosamines in Valsartan according to the Chinese...

Phosphorylated compounds such as nucleotides are known to interact with stainless steel components leading to recovery issues in HPLC and LC/MS. Instrument and column inertness ensure successful analysis. Discover more about the bio-inert analysis...