Pharma Science

Discover a method for the preparative purification of Ibuprofen

This application note describes a method for the preparative purification of Ibuprofen and its analogs using the Prominence™ UFPLC designed to improve the efficiency of your workflow.

Sub-picogram level quantitation of desmopressin

In this study, a successful micro LC-MS/MS method for the highly sensitive quantitation of desmopressin in human plasma is demonstrated. It shows how the QTRAP® 6500+ LC MS/MS system with OptiFlow™ Source coupled with a M5 MicroLC system provides...

High-speed analysis of pramipexole that meets regulatory compliance

This application note demonstrates a method for the high-speed analysis of pramipexole following the draft guidance of International Harmonization of Pharmacopoeias. It uses Shimadzu's integrated LC system, the Nexera™ - i MT. 

An improved immunoaffinity-micro LC-MS/MS workflow for quantifying trastuzumab emtansine

This study describes in detail an improved immunoaffinity-micro LC-MS/MS workflow for quantifying trastuzumab emtansine in mouse plasma using the SCIEX 6500+ QTRAP® System with OptiFlow™ Turbo V source and M5 MicroLC System.

Perform LCMS bioanalysis of antibody drugs using new nSMOL technology

This study describes the LCMS bioanalysis of antibody drugs using the Fab-selective proteolysis "nSMOL Method" offering an improvement of reaction conditions for automated analyses.

Determining the molecular weight for Dextran 40/60/70 according to USP/EP

PSS has produced an application note demonstrating a specific workflow in which its PSS WinGPC Software allows for calibration and molar mass determination for Dextran 40, 60 and 70 as stated by United States Pharmacopeia (USP) and European...

Determination of acid-neutralizing capacity according to USP general chapter <301>

Metrohm has produced an application note describing the straightforward determination of acid-neutralizing capacity (ANC) for numerous over-the-counter (OTC) antacids.

Trace element analysis of pharmaceutical products

This useful compendium from Thermo Fisher provides detailed methods for the analysis of trace elements in pharmaceutical products using AAS, ICP-OES and ICP-MS covered by the NEW USP chapters 232 and 233.

Doubling chromatographic throughput using dual LC for pharmaceutical analysis

Thermo Fisher Scientific has produced an application note describing a novel Dual LC workflow, which provides a unique concept by using two separated flow paths in one system. It shows how the Thermo Scientific Vanquish Duo system for Dual LC...

How to analyse small pharmaceuticals and peptide mixtures using chemically stable merged inorganic/organic silica material

Kromasil has produced an application note demonstrating how, by using merged inorganic/organic silica materials with newly developed C8, C18 or phenyl hexyl phases, it is possible to use a stationary phase with a wider pH range. 

Monitoring Antibody Oxidation at The Subunit Level

SCIEX has produced an application note demonstrating how to monitor biotherapeutic oxidation levels in a simple and automated way using the X500B QTOF system and powerful BioPharmaView™ Software.

Routine Workflow for Comparability Assessment of Protein Biopharmaceuticals using High-resolution LC-MS

SCIEX has produced an application note demonstrating using a reproducible and robust method for analysing intact biotherapeutic proteins on the X500B QTOF System with automated batch processing using BioPharmaView™ software.

    

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