Pharmaceutical Analysis Blog

Improve your bioprocessing applications for the purification of biomolecules

Tosoh Bioscience has produced Volume 1 of its 'Bioprocessing Application Notebook' that comprises over twenty application notes covering important aspects of biopharmaceutical purification.

How to analyse peptone samples using 2D–LC

This application from Agilent describes the 2D-LC analysis of complex peptones. Active solvent modulation proved to be valuable to maintain chromatographic performance and avoid breakthrough in the second dimension.

Headspace GC method for residual solvents analysis in pharmaceutical products

The aim of this study was to develop a rapid, cost-effective, modified USP <467> HS-GC-FID method for residual solvent determination in pharmaceutical products using the Thermo Scientific™ TriPlus™ 500 Headspace Autosampler and nitrogen as...

Determination of genotoxic nitrosamines in Valsartan with GC–MS

This application note provides an evaluation of the quantitative performance of the Thermo Scientific™ TriPlus™ 500 Gas Chromatography Headspace Autosampler for determination of genotoxic nitrosamines in Valsartan according to the Chinese...

HPLC-DAD analysis of nucleotides

Phosphorylated compounds such as nucleotides are known to interact with stainless steel components leading to recovery issues in HPLC and LC/MS. Instrument and column inertness ensure successful analysis. Discover more about the bio-inert...

Methods and Applications to Improve Pharmaceutical Workflows

Benefit from a series of educational resources aimed at pharmaceutical scientists, ranging from pharmaceutical impurity method development, to a complete HPLC workflow comprising multiple detectors, to strategies to improve productivity and...

Download now the Bioanalysis Quantitation Applications eBook Vol 2

The therapeutic potential of biologic modalities has increased, driving an inevitable move toward exploring more complex biotherapeutic molecule classes. As biotherapeutics become more complex, there is still a demand for superior quantification...

Discover a method for the preparative purification of Ibuprofen

This application note describes a method for the preparative purification of Ibuprofen and its analogs using the Prominence™ UFPLC designed to improve the efficiency of your workflow.

Sub-picogram level quantitation of desmopressin

In this study, a successful micro LC-MS/MS method for the highly sensitive quantitation of desmopressin in human plasma is demonstrated. It shows how the QTRAP® 6500+ LC MS/MS system with OptiFlow™ Source coupled with a M5 MicroLC system provides...

High-speed analysis of pramipexole that meets regulatory compliance

This application note demonstrates a method for the high-speed analysis of pramipexole following the draft guidance of International Harmonization of Pharmacopoeias. It uses Shimadzu's integrated LC system, the Nexera™ - i MT. 

An improved immunoaffinity-micro LC-MS/MS workflow for quantifying trastuzumab emtansine

This study describes in detail an improved immunoaffinity-micro LC-MS/MS workflow for quantifying trastuzumab emtansine in mouse plasma using the SCIEX 6500+ QTRAP® System with OptiFlow™ Turbo V source and M5 MicroLC System.

Perform LCMS bioanalysis of antibody drugs using new nSMOL technology

This study describes the LCMS bioanalysis of antibody drugs using the Fab-selective proteolysis "nSMOL Method" offering an improvement of reaction conditions for automated analyses.

    

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