Pharmaceutical Analysis Blog

Biosimilarity assessment and product quality attribute monitoring

In this application note, a Thermo Scientific™ HR-MAM workflow for biosimilarity assessment is evaluated. The study demonstrates the use of the workflow for sequence variant assessment and to monitor the variability of product quality attributes...

Comparative analysis of innovator and biosimilar mAbs using a multi-attribute method

This application note demonstrates how a high resolution multi-attribute method (HR-MAM) provides a streamlined workflow for the identification, robust relative quantitation, and monitoring of product quality attributes (PQAs).

Applications to Improve Your Biopharmaceutical Analyses

Separation Science, in collaboration with Thermo Fisher Scientific, offers a selection of application notes relevant for biopharmaceutical analysis. Discover the latest advances in high-resolution accurate-mass (HRAM) mass spectrometry. Learn...

Refining charge variant analysis of mAbs

Charge variant analysis is a demanding application for applied liquid chromatography systems due to the use of highly corrosive buffer salts in combination with very shallow gradients for optimal separation. Separation Science, in collaboration...

High-performance CQA Analysis in Biopharma

With challenging applications and strict time and quality constraints, biopharmaceutical analysis can be especially demanding.

Achieve simultaneous analysis of monoclonal antibodies using Dual LC

This application note will teach you how to perform simple and rapid high-throughput analysis of biotherapeutics using different chromatographic techniques at one time.

Comprehensive cell culture profiling using Q-TOF MS/MS

This application note will help you readily perform comprehensive targeted analysis of cell culture media and understand how to identify and quantify unknown cell culture media components with high accuracy using Q-TOF MS/MS.

Improve your bioprocessing applications for the purification of biomolecules

Tosoh Bioscience has produced Volume 1 of its 'Bioprocessing Application Notebook' that comprises over twenty application notes covering important aspects of biopharmaceutical purification.

Methods and applications in biopharmaceutical characterization eBook

Are you looking for solutions to your biopharmaceutical workflows? Struggling with your intact protein analysis, or need help with glycosylation studies? If so Separation Science, in collaboration with Thermo Fisher Scientific, has developed an...

The importance of particle pore diameter for biomacromolecule separations

Recently, the evolution of middle to large biomacromolecules such as peptides or proteins is apparent in the market of pharmaceutical drugs in addition to traditional active ingredients based on small molecules. The use of peptides for clinical...

Methods and Applications to Improve Pharmaceutical Workflows

Benefit from a series of educational resources aimed at pharmaceutical scientists, ranging from pharmaceutical impurity method development, to a complete HPLC workflow comprising multiple detectors, to strategies to improve productivity and...

Download now the Bioanalysis Quantitation Applications eBook Vol 2

The therapeutic potential of biologic modalities has increased, driving an inevitable move toward exploring more complex biotherapeutic molecule classes. As biotherapeutics become more complex, there is still a demand for superior quantification...

    

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