Pharmaceutical Analysis Blog

Stacked injection for high efficiency isomer preparation with preparative scale SFC

This article describes the stacked injection functionality of Shimadzu's Nexera UC Prep system to improve the efficiency of preparative operations.

Method for the analysis of residual solvents in pharmaceuticals

This application note describes a method for the analysis of Class 2 solvents (water-soluble samples) that are unsuited to Headspace GC methods.

Perform high-speed analysis of linezolid

This application note describes the high-speed analysis of linezolid following the draft guidance of International Harmonization of Pharmacopoeias.

Comprehensive cell culture profiling using Q-TOF MS/MS

This application note will help you readily perform comprehensive targeted analysis of cell culture media and understand how to identify and quantify unknown cell culture media components with high accuracy using Q-TOF MS/MS.

Effective API analysis using UHPLC-UV and a single quadrupole mass detector

This application note demonstrates how the combination of UV and a single quadrupole mass detector is a powerful tool for (active pharmaceutical ingredient) API analysis in early stages of development, enabling confirmation of expected impurities.

Learn how to conduct structural analysis of impurities in pharmaceuticals

This application note will help you understand how trap-free 2D LC-MS allows online conversion of non-volatile to volatile mobile phase conditions and how the LCMS-9030’s high mass accuracy can be used to conduct structural analysis of impurities.

PREP 2021 Symposium + Exhibit on Preparative & Process Chromatography

We look forward to seeing you at PREP2021 to be held at the Hyatt Regency Inner Harbor Hotel in Baltimore, MD, USA, on June 6-10, 2021. Find out more about what's going on and why you should be attending... PREP is the longest running, now in its...

Detection in Capillary Electrophoresis (CE)

We went through the fundamentals, the separation medium BGE, the capillary and injection in capillary electrophoresis. In this article of CE Solutions we will reach the end of the system, the detector. We will discuss the most popular detection...

Principles of HPLC Validation - Training Module 5: Data Analysis

A short course in the systematic validation of HPLC methods. This section covers various aspects of data analysis including how and when external standardization, internal standardization, and the method of standard additions should be used for...

Injection Precision and Sensitivity in Capillary Electrophoresis (CE)

We discussed the significance of a constant electro-osmotic flow and good capillary conditioning for precision in our CE methods. Now we look at the importance of injection settings for precision. We will also have a first look at sample stacking...

Principles of HPLC Validation - Training Module 4: Quality by Design and Robustness

A short course in the systematic validation of HPLC methods. We introduce Quality by Design (QbD) as a laboratory lifestyle described in ICH Q8. QbD translates into more efficient method development, easier validation, more manageable methods in...

Your route to successful characterization of biopharmaceuticals


Although “small molecule” and “biomolecular” separations have traditionally been considered as separate activities, analysts in the biopharmaceutical industry regularly have to deal with...


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