Pharmaceutical Analysis

Advances in Mass Spectrometry Instrument Intelligence

Separation Science, in collaboration with Agilent, offers the 'Advances in Mass Spectrometry Instrument Intelligence' eBook. Download it and learn how to develop LC/MS methods faster, ensure confidence in results and maximize uptime.

Analysis of Oligonucleotides by SEC-MALS

This article from Issue 13 of the Analytix Reporter demonstrates the ability of TSKgel® UP-SW2000 size exclusion chromatography (SEC) columns to distinguish between oligonucleotide species differing by one base in length. To further analyse...

Synthetic Carbon Adsorbents for Removal of Host Cell Proteins in Monoclonal Antibody Purification

The removal of host cell proteins (HCPs) in the manufacturing of mAbs remains a challenge. This article, from Issue 13 of the Analytix Reporter, teaches you how to improve depletion of difficult-to-remove lower molecular weight and hydrophobic HCPs...

Fast Analysis of Intact Therapeutic Monoclonal Antibody Trastuzumab

This article, from Issue 13 of the Analytix Reporter, demonstrates a high-resolution and reproducible analysis of mAb trastuzumab in less than 5 minutes using a BIOshell™ A400 Protein C4 column. More importantly the optimized method was able to...

What You Need to Know about Computerized System Validation: GAMP 5 2nd Edition

This webinar takes a look at the contents of the long awaited GAMP®5 Version 2 release to examine what has truly changed since the Version 1 release, with special focus on what might impact regulated laboratories in the pharma, biopharma, and...

Understanding of USP<1058> updates and insights in regulations

Learn about how USP <1058> aligns with GAMP® 5, the core elements of the <1058> instrument life-cycle framework, and areas of <1058> the USP are exploring improvements in by attending this upcoming webinar.

(U)HPLC Analysis of Biopharmaceuticals: Quality Attributes and How to Analyse Them

Join Separation Science and Tosoh Bioscience for a tutorial series designed to improve your (U)HPLC analysis of biotherapeutics.

High-Throughput Lead Discovery with Agilent RapidFire/MS Systems

In this application note a stearoyl-coenzyme A desaturase (SCD) assay is used to illustrate the power of Agilent RapidFire/MS systems for screening intractable targets.

Ultrafast Analysis of Levetiracetam in Serum

This application note evaluates the ability of an ultrafast SPE/MS/MS system (Agilent RapidFire high-throughput MS system) which is capable of analysis times of <10 seconds per sample to analyze levetiracetam in human serum.

Fragment-Based Drug Discovery: Comparing Labeled and Label-Free Screening

This application note describes screening of β-amyloid secretase (BACE-1) using fluorescence spectroscopy and ultrafast SPE/MS/MS.

Analysis of Lipid Nanoparticle Composition

Separation Science, in collaboration with Agilent, offers an application note covering a liquid chromatographic method development for the analysis of the lipid components of patisiran.

High-Throughput LC/MS Applications

Separation Science, in collaboration with Agilent, offers an eBook focusing on high-throughput LC-MS applications of the RapidFire 400 system. 

Regulatory Challenges in Pharma 4.0

In this forum, the expert panel discuss acceptance from regulators on new technology, and other key issues regarding Pharma 4.0. 

Impact of COVID on Pharma 4.0

In this forum, the expert panel discuss changes to the pharmaceutical manufacturing processes during and post the COVID pandemic including what technologies have been adopted to increase speed and efficiencies. 

Purification of Single-Stranded RNA Oligonucleotides

In this application note purification of a single-stranded RNA oligonucleotide by ion pair reversed-phase HPLC is demonstrated, achieving > 99% pure fraction pool with a yield of > 56%.

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