This application note will help you understand how trap-free 2D LC-MS allows online conversion of non-volatile to volatile mobile phase conditions and how the LCMS-9030’s high mass accuracy can be used to conduct structural analysis of impurities.
We look forward to seeing you at PREP2021 to be held at the Hyatt Regency Inner Harbor Hotel in Baltimore, MD, USA, on June 6-10, 2021. Find out more about what's going on and why you should be attending... PREP is the longest running, now in its...
A short course in the systematic validation of HPLC methods. This section covers various aspects of data analysis including how and when external standardization, internal standardization, and the method of standard additions should be used for...
A short course in the systematic validation of HPLC methods. We introduce Quality by Design (QbD) as a laboratory lifestyle described in ICH Q8. QbD translates into more efficient method development, easier validation, more manageable methods in...
A short course in the systematic validation of HPLC methods. We go through the various validation steps in detail. We review the key regulatory requirements from the International Committee on Harmonization (ICH), which also apply to the national...
A short course in the systematic validation of HPLC methods. The validation process is best started with the first injection during method development. We discuss the importance of having an overall plan for the method development / validation /...
Would you like to learn more about the vital role of compendial methods in pharmaceutical analysis and how, by making adjustments to them, laboratory efficiency can be increased and cost decreased? If so, this on-demand webinar will provide the...
A short course in the systematic validation of HPLC methods. We start by taking an overview of the validation process and review some of the key references that will be useful in setting up a validation process. We also discuss the terminology...
Once a chemical hit is found through a library screening process and verified, the synthetic route is then optimized. This step involves an iterative process of synthesis and reactivity measurements of the new compound(s) to further develop the...
In convergence chromatography (CC), the modes of interaction between the stationary phase and the solute are numerous, including hydrogen bonding, hydrophobic interactions, dipolar and polarizability interactions and solute partitioning [1]....
This application note describes a method for the preparative purification of Ibuprofen and its analogs using the Prominence™ UFPLC designed to improve the efficiency of your workflow.
This application note demonstrates a method for the high-speed analysis of pramipexole following the draft guidance of International Harmonization of Pharmacopoeias. It uses Shimadzu's integrated LC system, the Nexera™ - i MT.
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