Pharma Science

A short course in the systematic validation of HPLC methods. We start by taking an overview of the validation process and review some of the key references that will be useful in setting up a validation process. We also discuss the terminology...

Once a chemical hit is found through a library screening process and verified, the synthetic route is then optimized. This step involves an iterative process of synthesis and reactivity measurements of the new compound(s) to further develop the...

In convergence chromatography (CC), the modes of interaction between the stationary phase and the solute are numerous, including hydrogen bonding, hydrophobic interactions, dipolar and polarizability interactions and solute partitioning [1]....

This application note describes a method for the preparative purification of Ibuprofen and its analogs using the Prominence™ UFPLC designed to improve the efficiency of your workflow.

This application note demonstrates a method for the high-speed analysis of pramipexole following the draft guidance of International Harmonization of Pharmacopoeias. It uses Shimadzu's integrated LC system, the Nexera™ - i MT. 

This application demonstrates an effective method for the analysis irbesartan using Shimadzu's integrated LC system, the Nexera™ - i MT. 

Thermo Fisher Scientific has produced an application note describing a novel Dual LC workflow, which provides a unique concept by using two separated flow paths in one system. It shows how the Thermo Scientific Vanquish Duo system for Dual LC...

Kromasil has produced an application note demonstrating how, by using merged inorganic/organic silica materials with newly developed C8, C18 or phenyl hexyl phases, it is possible to use a stationary phase with a wider pH range.