Pharmaceutical Analysis

High-Throughput Lead Discovery with Agilent RapidFire/MS Systems

In this application note a stearoyl-coenzyme A desaturase (SCD) assay is used to illustrate the power of Agilent RapidFire/MS systems for screening intractable targets.

Ultrafast Analysis of Levetiracetam in Serum

This application note evaluates the ability of an ultrafast SPE/MS/MS system (Agilent RapidFire high-throughput MS system) which is capable of analysis times of <10 seconds per sample to analyze levetiracetam in human serum.

Fragment-Based Drug Discovery: Comparing Labeled and Label-Free Screening

This application note describes screening of β-amyloid secretase (BACE-1) using fluorescence spectroscopy and ultrafast SPE/MS/MS.

High-Throughput LC/MS Applications

Separation Science, in collaboration with Agilent, offers an eBook focusing on high-throughput LC-MS applications of the RapidFire 400 system. 

[eBook] Pharmaceutical and biopharmaceutical solutions

This eBook contains a selection of application notes relevant for pharmaceutical and biopharmaceutical analysis using HPLC / (U)HPLC or LC-MS/MS.

Latest Solutions for Nitrosamine Analysis

Separation Science, in collaboration with Shimadzu, offers a series of application notes describing the quantitation of various nitrosamines in drugs and solvents using its LC/MS or GC/MS instruments. Click below to download your personal copies.

Biosimilarity assessment and product quality attribute monitoring

In this application note, a Thermo Scientific™ HR-MAM workflow for biosimilarity assessment is evaluated. The study demonstrates the use of the workflow for sequence variant assessment and to monitor the variability of product quality attributes in...

Applications to Improve Your Biopharmaceutical Analyses

Separation Science, in collaboration with Thermo Fisher Scientific, offers a selection of application notes relevant for biopharmaceutical analysis. Discover the latest advances in high-resolution accurate-mass (HRAM) mass spectrometry. Learn more...

How to Select a Reproducible Starting Point in HPLC Method Development

Separation Science, in collaboration with Phenomenex offers an on-demand webinar 'HPLC/UHPLC Reversed-Phase Method Development: Selecting a Reproducible Starting Point' with pharma industry expert, Dr Phil Koerner.

Learn how to conduct structural analysis of impurities in pharmaceuticals

This application note will help you understand how trap-free 2D LC-MS allows online conversion of non-volatile to volatile mobile phase conditions and how the LCMS-9030’s high mass accuracy can be used to conduct structural analysis of impurities.

Sub-picogram level quantitation of desmopressin

In this study, a successful micro LC-MS/MS method for the highly sensitive quantitation of desmopressin in human plasma is demonstrated. It shows how the QTRAP® 6500+ LC MS/MS system with OptiFlow™ Source coupled with a M5 MicroLC system provides...

An improved immunoaffinity-micro LC-MS/MS workflow for quantifying trastuzumab emtansine

This study describes in detail an improved immunoaffinity-micro LC-MS/MS workflow for quantifying trastuzumab emtansine in mouse plasma using the SCIEX 6500+ QTRAP® System with OptiFlow™ Turbo V source and M5 MicroLC System.

Addressing the key challenges in the quantification of Trastuzumab

SCiEX has produced a technical note describing an immunoaffinity-high resolution accurate mass assay for the pre-clinical quantification of Trastuzumab in rat plasma.

Therapeutic peptide catabolite identification

Find, Identify and Confirm Peptide Catabolites Using MetabolitePilotTM 2.0 Software and the Advanced Biotransform Solution.

Metabolite identification of payload species of antibody drug conjugates

SCIEX has produced a technical note describing metabolite identification of payload species of antibody drug conjugates with noncleavable linkers using MetabolitePilot™ 2.0 software and TripleTOF® 6600 systems.

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