Pharma Science

Sub-picogram level quantitation of desmopressin

In this study, a successful micro LC-MS/MS method for the highly sensitive quantitation of desmopressin in human plasma is demonstrated. It shows how the QTRAP® 6500+ LC MS/MS system with OptiFlow™ Source coupled with a M5 MicroLC system provides...

An improved immunoaffinity-micro LC-MS/MS workflow for quantifying trastuzumab emtansine

This study describes in detail an improved immunoaffinity-micro LC-MS/MS workflow for quantifying trastuzumab emtansine in mouse plasma using the SCIEX 6500+ QTRAP® System with OptiFlow™ Turbo V source and M5 MicroLC System.

Addressing the key challenges in the quantification of Trastuzumab

SCiEX has produced a technical note describing an immunoaffinity-high resolution accurate mass assay for the pre-clinical quantification of Trastuzumab in rat plasma.

Therapeutic peptide catabolite identification

Find, Identify and Confirm Peptide Catabolites Using MetabolitePilotTM 2.0 Software and the Advanced Biotransform Solution.

Metabolite identification of payload species of antibody drug conjugates

SCIEX has produced a technical note describing metabolite identification of payload species of antibody drug conjugates with noncleavable linkers using MetabolitePilot™ 2.0 software and TripleTOF® 6600 systems.

Improve your peptide mapping and PTM analysis skills

Peptide mapping is critical for characterizing protein drugs and monitoring product critical quality attributes (CQAs) in biopharma. Due to the heterogenous nature of protein drugs, comprehensive analytical characterization is required for...

Enabling single-software multiple attribute methodology for assessment of biopharmaceutical product quality attributes

This technical note from SCIEX will highlight how to implement a complete and easy-to-use Multiple Attribute Methodology (MAM) workflow for biotherapeutic PQA monitoring using accurate mass LC–MS. It will demonstrate how this new streamlined MAM...

Achieve high-throughput LC/MS purification of pharmaceutical impurities

Agilent Technologies has produced an application note describing the separation and purification of acetaminophen (paracetamol) and six common impurities listed in the European and United States Pharmacopoeias.

[On-Demand Webinar] Accelerating Large Molecule LC-MS Method Development

Rapid development of sensitive and selective peptide bioanalytical methods are required to support the expanding protein component of pharmaceutical companies’ drug pipeline. Choosing the best MRM for a large molecule peptide or protein is a...

Confident pharmaceutical impurity profiling using high-res mass spec

Attend this on-demand webinar and learn about workflows involved in pharmaceutical impurity analysis and API stability studies, and how to deliver confidence in the identification of unknown impurities...

    

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