Pharmaceutical Analysis

Stacked injection for high efficiency isomer preparation with preparative scale SFC

This article describes the stacked injection functionality of Shimadzu's Nexera UC Prep system to improve the efficiency of preparative operations.

Reaction Monitoring with UltraPerformance Convergence Chromatography

Once a chemical hit is found through a library screening process and verified, the synthetic route is then optimized. This step involves an iterative process of synthesis and reactivity measurements of the new compound(s) to further develop the drug...

Practical Considerations for Achiral Analysis of Pharmaceutical Compounds Using Convergence Chromatography

In convergence chromatography (CC), the modes of interaction between the stationary phase and the solute are numerous, including hydrogen bonding, hydrophobic interactions, dipolar and polarizability interactions and solute partitioning [1]. These...

Software Solutions Enabling Open Access Workflows

This on-demand webinar will discuss Waters® Openlynx™ Open Access Solutions and new workflows designed to streamline the implementation of supercritical fluid chromatography (SFC) technologies focused on supporting Medicinal Chemistry and Synthetic...

Separation of Amphetamine Enantiomers by SFC

Agilent Technologies has produced an application note demonstrating the separation of enantiomers of amphetamines and their positional isomers on chiral phase columns using SFC with mass spectrometry.

Chiral Multicolumn Method Development on the Agilent 1260 Infinity II Analytical SFC System

Agilent Technologies has produced an application note demonstrating the use of the Agilent ChemStation Method Scouting Wizard for the development of a chiral separation method on the Agilent 1260 Infinity II Analytical SFC system. The SFC system was...

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