Pharmaceutical Analysis Blog

Protein Binding Determination - Comparison Study of Techniques & Devices

This article from Issue 10 of the Analytix Reporter, produced by Merck, provides a comparative study between the Supel™ BioSPME 96-Pin device and the rapid equilibrium dialysis technique.

Analysis of Fingolimod Hydrochloride According to USP Monograph Guidelines

This article from Issue 10 of the Analytix Reporter, produced by Merck, demonstrates a rapid, accurate, and simple method that was developed for the total chromatographic purity analysis of Fingolimod hydrochloride by HPLC-DAD, well within the...

Comparative analysis of innovator and biosimilar mAbs using a multi-attribute method

This application note demonstrates how a high resolution multi-attribute method (HR-MAM) provides a streamlined workflow for the identification, robust relative quantitation, and monitoring of product quality attributes (PQAs).

Reliably quantify nitrosamine impurities in drugs using an HRAM LC-MS method

This application note will enable you to detect and quantify nine nitrosamines with a single liquid chromatography-high resolution accurate mass (HRAM) mass spectrometry method.

Build the Lab of the Future Today for Pharma 4.0

Pharmaceutical companies can be more cost-efficient, more connected and more productive with Pharma 4.0 by modernizing the laboratories. The transformation into the Lab of the Future necessitates the use of digitalization and connectivity. In...

Strengthening Asia’s Scientific Community for Tomorrow’s Pharma 4.0

While Asia’s pharmaceutical businesses cope with the changes in operating environments, the scientific community, involving local and international scientists, chemists and laboratory professionals, needs to continue to strengthen and grow...

Perform high-speed analysis of linezolid

This application note describes the high-speed analysis of linezolid following the draft guidance of International Harmonization of Pharmacopoeias.

Effective API analysis using UHPLC-UV and a single quadrupole mass detector

This application note demonstrates how the combination of UV and a single quadrupole mass detector is a powerful tool for (active pharmaceutical ingredient) API analysis in early stages of development, enabling confirmation of expected impurities.

Determination of genotoxic nitrosamines in Valsartan with GC–MS

This application note provides an evaluation of the quantitative performance of the Thermo Scientific™ TriPlus™ 500 Gas Chromatography Headspace Autosampler for determination of genotoxic nitrosamines in Valsartan according to the Chinese...

Effective analysis of residual solvents according to USP <467> method using a static headspace autosampler

Thermo Fisher Scientific has produced an application note with the goal of evaluating the performance of a new Thermo Scientific™ TriPlus™ 500 Gas Chromatography Headspace Autosampler for the determination of residual solvent content in...

How to analyse irbesartan using an integrated LC system

This application demonstrates an effective method for the analysis irbesartan using Shimadzu's integrated LC system, the Nexera™ - i MT. 

Addressing the key challenges in the quantification of Trastuzumab

SCiEX has produced a technical note describing an immunoaffinity-high resolution accurate mass assay for the pre-clinical quantification of Trastuzumab in rat plasma.

    

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