Pharmaceutical Analysis Blog

An improved immunoaffinity-micro LC-MS/MS workflow for quantifying trastuzumab emtansine

This study describes in detail an improved immunoaffinity-micro LC-MS/MS workflow for quantifying trastuzumab emtansine in mouse plasma using the SCIEX 6500+ QTRAP® System with OptiFlow™ Turbo V source and M5 MicroLC System.

How to analyse irbesartan using an integrated LC system

This application demonstrates an effective method for the analysis irbesartan using Shimadzu's integrated LC system, the Nexera™ - i MT. 

Perform LCMS bioanalysis of antibody drugs using new nSMOL technology

This study describes the LCMS bioanalysis of antibody drugs using the Fab-selective proteolysis "nSMOL Method" offering an improvement of reaction conditions for automated analyses.

Determining the molecular weight for Dextran 40/60/70 according to USP/EP

PSS has produced an application note demonstrating a specific workflow in which its PSS WinGPC Software allows for calibration and molar mass determination for Dextran 40, 60 and 70 as stated by United States Pharmacopeia (USP) and European...

Software Solutions Enabling Open Access Workflows

This on-demand webinar will discuss Waters® Openlynx™ Open Access Solutions and new workflows designed to streamline the implementation of supercritical fluid chromatography (SFC) technologies focused on supporting Medicinal Chemistry and...

Addressing the key challenges in the quantification of Trastuzumab

SCiEX has produced a technical note describing an immunoaffinity-high resolution accurate mass assay for the pre-clinical quantification of Trastuzumab in rat plasma.

Therapeutic peptide catabolite identification

Find, Identify and Confirm Peptide Catabolites Using MetabolitePilotTM 2.0 Software and the Advanced Biotransform Solution.

Metabolite identification of payload species of antibody drug conjugates

SCIEX has produced a technical note describing metabolite identification of payload species of antibody drug conjugates with noncleavable linkers using MetabolitePilot™ 2.0 software and TripleTOF® 6600 systems.

Improve your peptide mapping and PTM analysis skills

Peptide mapping is critical for characterizing protein drugs and monitoring product critical quality attributes (CQAs) in biopharma. Due to the heterogenous nature of protein drugs, comprehensive analytical characterization is required for...

Comparing in-solution digestion approaches to quantify therapeutic mAb modifications

Do you work with therapeutic recombinant mAbs? Need to understand the extent of post-translational modifications? If so, you'll be interested in this comparison of in-solution protein digestion approaches...

SMARTLab launched by Singapore Polytechnic and Shimadzu to prepare for the digitalised laboratory

To better prepare QA/QC lab analysts and technicians for digitalisation, Singapore Polytechnic’s (SP) School of Chemical and Life Sciences (CLS) and Shimadzu, have set up a Scalable, Manageable, Automated, Regulated and Total-Compliant Laboratory...

The biopharma applications compendium

Are you looking for a comprehensive source of applications information for biopharmaceutical methods? If so, this biopharma applications compendium is what you need. Sign up to the Separation Science 'Biopharmaceutical Characterization Resource...

    

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