Pharmaceutical Analysis

Join Separation Science in collaboration with Bruker Daltonics for an on-demand presentation on the advancement of CRISPR-based gene editing tools into biotherapeutics offering the potential for cures to genetic disorders and for new treatment...

In extractables studies, LC/UV/MS is commonly used to detect and annotate the non-volatile fraction of compounds.

Separation Science, in collaboration with Agilent, offers the 'Advances in Mass Spectrometry Instrument Intelligence' eBook. Download it and learn how to develop LC/MS methods faster, ensure confidence in results and maximize uptime.

In this application note a stearoyl-coenzyme A desaturase (SCD) assay is used to illustrate the power of Agilent RapidFire/MS systems for screening intractable targets.

This application note evaluates the ability of an ultrafast SPE/MS/MS system (Agilent RapidFire high-throughput MS system) which is capable of analysis times of <10 seconds per sample to analyze levetiracetam in human serum.

This application note describes screening of β-amyloid secretase (BACE-1) using fluorescence spectroscopy and ultrafast SPE/MS/MS.

In this application note purification of a single-stranded RNA oligonucleotide by ion pair reversed-phase HPLC is demonstrated, achieving > 99% pure fraction pool with a yield of > 56%.

This eBook contains a selection of application notes relevant for pharmaceutical and biopharmaceutical analysis using HPLC / (U)HPLC or LC-MS/MS.

In this application note, a Thermo Scientific™ HR-MAM workflow for biosimilarity assessment is evaluated. The study demonstrates the use of the workflow for sequence variant assessment and to monitor the variability of product quality attributes in...

This application note demonstrates how a high resolution multi-attribute method (HR-MAM) provides a streamlined workflow for the identification, robust relative quantitation, and monitoring of product quality attributes (PQAs).

Separation Science, in collaboration with Thermo Fisher Scientific, offers a selection of application notes relevant for biopharmaceutical analysis. Discover the latest advances in high-resolution accurate-mass (HRAM) mass spectrometry. Learn more...

Charge variant analysis is a demanding application for applied liquid chromatography systems due to the use of highly corrosive buffer salts in combination with very shallow gradients for optimal separation. Separation Science, in collaboration with...

With challenging applications and strict time and quality constraints, biopharmaceutical analysis can be especially demanding.

This application note will teach you how to perform simple and rapid high-throughput analysis of biotherapeutics using different chromatographic techniques at one time.

This application note will help you readily perform comprehensive targeted analysis of cell culture media and understand how to identify and quantify unknown cell culture media components with high accuracy using Q-TOF MS/MS.