John Dolan: I often get asked which HPLC system or manufacturer is the best. In days of yore, there was quite a bit of difference in quality and reliability between instruments sold by different manufacturers, but that is no longer true.
This technical article discusses whether high-pressure mixing or low-pressure mixing are better.
Q: I have a validated stability-indicating assay that uses one manufacturer’s C18 column. I know of another column manufacturer where I can get an equivalent C18 column for half the price of the column stated in the method. Will changing columns...
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