Liquid Chromatography

TUTORIAL SERIES: Ion Chromatography Fundamentals

Need to know more about ion chromatography, new to the technique and not sure where to start, or just need a refresher? If the answer to any of the above is yes, then this 'Basics of Ion Chromatography' learning hub is just what you need.

TAN/TBN titration in petrochemical samples - walk away automation for up to 112 samples

The OMNIS Sample Robot from Metrohm meets the need of petrochemical laboratories for automated TAN/TBN determinations in large numbers of samples.

Achieve high-throughput analysis of cannabinoids by LC-UV

The LC-UV method shown in this application note from Restek uses a Raptor ARC-18 column to fully resolve 16 major and most frequently observed minor cannabinoids for which commercial standards are available.

Shodex HILIC tutorial

This video provides a general overview of hydrophilic interaction chromatography, also known as HILIC.HILIC separation is based on hydrophilic interaction. HILIC uses the same solvent as with reserved-phase chromatography (acetonitrile / water /...

Improving ROI in liquid chromatography

Looking to calculating the financial benefit of replacing your current LC instrumentation? This white paper should help...

Preparative-scale chromatography solutions

Preparative-scale chromatography plays a critical role in applications where compounds must be synthesized, identified, isolated, purified, characterized, screened, and tested. Waters AutoPurification Systems offer scalable prep configurations,...

Developing, Testing and Troubleshooting Chromatography Method Transfer

The transfer of chromatographic methods occurs at many stages in the development and production of a product. In its simplest form, the method is moved from one laboratory to another within the same organization, holding all instrumental and...

Understanding GPC/SEC - Finding the Right Particle Size and Pore Size

Want to understand what the correct criteria for column selection should be based on? If so, this tutorial is for you...

Understanding GPC/SEC - Unexpected Peak Shapes

Do you find weird peak shapes in your chromatograms? Not sure if they are real or artifacts?

Understanding GPC/SEC - How to deal with pressure problems

So you're using gel permeation chromatography (GPC) / size exclusion chromatography (SEC) but are experiencing problems with your system pressure. What do you do?

The Case of the Unintentional Ion-Pairing Reagent

Shifting retention times within a sample batch can be a real source of headaches in the routine HPLC laboratory. Previously we talked about the kind of retention drift experienced by some HPLC methods for the first few injections. This often is...

Why do retention times drift for the first few injections of an HPLC method?

How many of you have experienced this? You think you’ve fully equilibrated the HPLC column by running mobile phase through it for 30 min, but for the first 3 or 4 injections, the retention times drift a little, finally settling down after half a...