Liquid Chromatography

Synthetic carbon separation media for procss and preparative chromatography

Discover the features, advantages and benefits of synthetic carbon separation media in both liquid and gas purifications and how they bring value to a wide range of LPLC applications for both small and large molecule separations by attending this...

Applications for HPLC Analysis

These latest application notes cover a wide range of subjects for HPLC analysis such as separation of water-soluble vitamins, high-throughput bottom-up proteome profiling, mRNA impurity determination, high-throughput analysis of oligonucleotides and...

Tips & Tricks: Karl Fischer Titration

Some samples do not easily release water for Karl Fischer determinations. So, what are the workable options in such instances? This article from Issue 12 of the Analytix Reporter, produced by Merck, discusses the steps that can be taken to release...

SEC overview of the principles and techniques to obtain reliable protein size-based-separations

Size-Exclusion Chromatography (SEC) is a powerful technique for protein characterization that requires an understanding of the principles to be successful. In this open-access course, we will discuss the history and science of SEC, its strengths and...

How to improve method robustness through control of unwanted interactions

Successful chromatographic separations are as much about preventing the interactions you don’t want, as it is about creating the interactions you need. This open-access course is designed to take you from beginner to advanced in controlling the...

Understanding LC Column Attributes - What's Important for Your Chromatography?

Have you ever wondered how the LC column creates a separation? What attributes are important, what do they do, and how to use them to your advantage? This open-access course is designed to take you from beginner to advanced in understanding column...

What’s New at the Largest Conference in the World Covering All Aspects of Separations and Analyses Carried Out in Liquid-Phase

Join scientists from around the world at the 50th sequel of the longest-running, largest, and most recognized conference in the world covering all aspects of Separations and Analyses carried out in Liquid Phase. HPLC 2022 will take place on June...

Conquering Orbital Ion Trap Limitations

This eBook demonstrates the six coveted advantages you gain with the Agilent 6546 LC/Q-TOF.

HPLC Tips & Tricks: Mobile Phase Preparation - Buffers

The mobile phase in HPLC strongly influences chromatographic separations. Its preparation can prove to be a source of trouble for a method, if not done correctly and consistently. Part two of this series on mobile phase preparation focuses on...

HPLC Products: The Best Choice for Any LC Instrument

In this article from Issue 11 of the Analytix Reporter, produced by Merck, learn about the Supelco® HPLC columns portfolio and the best practices for connecting the column to any instrument to get maximum performance.

Stable Isotope-Labeled Amino Acid Mixes

This article from Issue 11 of the Analytix Reporter, produced by Merck, describes the addition of two new certified solution mixtures of labeled amino acids to the company's portfolio. These certified reference material (CRM) mixes are suitable for...

HPLC tips & tricks - increase your HPLC/UHPLC method sensitivity

The sensitivity of a chromatographic method might be described by its limit of detection (LOD). LOD is usually defined as the minimum detectable amount or concentration of a component that can be reliably detected using a given analytical method....

HPLC Tips & Tricks - Mobile Phase Preparation

The mobile phase in HPLC strongly influences the chromatographic separation. Its preparation can be a source of trouble for a method, if not done correctly and consistently. This article provides some suggestions and practical tips for the mobile...

Implementing Robustness Testing for HPLC Methods

In this article the selection of appropriate robustness factors and factor levels relating to the mobile phase will be discussed and in particular, the volume fraction of the organic solvent in the mobile phase for reversed phase HPLC.

Advanced LC systems that even support remote working

Shimadzu has announced the release of its “Advanced i-Series” liquid chromatographs meeting user demands for analysing a large number of samples or quickly re-processing data even when working from home.

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