Liquid Chromatography

Ion suppression in Biological Sample Analysis: You May or May Not See It but It’s There

Interferences exist in every chromatographic analysis whether they are recognized or not. Interferences can be visible in your chromatogram and present themselves as reduced peak area counts, split peaks, shoulders around the peak, or peak...

Understanding Your Sample Preparation Options – Why “Mixing and Matching” Should Be In Your Sample Prep Tool Kit

A successful chromatographic analysis starts with the sample. Sample selection, collection, transportation, preservation, storage, and sampling protocol are all aspects of testing that need to be considered in the context of your analytical...

Food Analysis: What’s Changing and What Are My Sample Prep Options?

While food and beverage imports and exports continue to increase, regulating bodies are taking a greater interest in these activities that can affect public health. Since the early 2000s, worldwide food imports have increased dramatically, as have...

When 'Just Enough' is Not Enough — Part II

In the last column, we discussed ‘just enough’ sample preparation techniques, such as filtration, protein precipitation, extraction partitioning, solid-supported liquid extraction and QuEChERS. Now we will discuss when ‘just enough’ is not enough...

Quantitative Accuracy and Sample Preparation: Pre-Preparation Steps to Improve Results

We’ve covered many of the types of sample preparation options available to make samples ready for instrumental analysis by gas or liquid chromatography and mass spectrometry detection. There are techniques such as QuEChERS, liquid-liquid extraction...

Will QuEChERS Work for Me?

QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) is a sample preparation technique used primarily in the food industry to extract and clean up samples for instrumental analysis. Originally, the QuEChERS approach was developed for multi-residue...

Just Enough Sample Preparation

This technical article shows how sample preparation is an integral part to successful chromatographic analysis and how selecting the right sample preparation technique is dependent upon a number of factors.

Innovative septa for your SPME Arrow applications

Analysts have long enjoyed the benefits of Merlin Microseal septa for their traditional and SPME fiber injections—and now, you can switch to these innovative septa for your SPME Arrow applications, too!

Get your sample preparation strategies right for good chromatography

This November in Singapore, Separation Science in collaboration with sample preparation expert Ronald Majors, will be providing a one-day training course on sample preparation starteges for good chromatography.

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