Mass Spectrometry

A successful lab requires more than just optmized workflows - at its heart it needs a confident, well-trained team of scientists.

As analytical chemists, we spend considerable time thinking about and working with basic scientific principles combined with the technology and products that allow us to solve our analytical problems. However, it is essential for success of any...

The Wiley Registry of Mass Spectral Data has contained a number of “single-peak” spectra such as those shown in Figure 1. Such spectra in an EI database used for the identification of unknowns based on their mass spectra are of no benefit. These...

This technical article is looking at the incorporation of FAIMS/DMS into a conventional LC/MS system to provide an added dimension of ion separation which is orthogonal to both chromatographic and mass spectrometric separation mechanisms. In a...

Ion mobility spectrometry (IMS), by itself has found a niche in many areas including security screening, environmental monitoring, military applications, and analytical laboratory use. The technique is not mass spectrometry, however it is related to...

Many analysts never consider anything beyond the electrospray interface for LC/MS. Electrospray is undeniably a very flexible technique. It works well for macromolecules as well as small molecules, positive and negative ion mode, and is a great...

MS/MS (Tandem) spectra can be used to identify unknowns employing library searches. This is accomplished in much the same approach as that employed for EI GC-MS with the NIST search software. The much improved NIST Search Version 2.4 is included...

Mass spectral libraries are a powerful tool for the identification of organic compounds in complex mixtures by mass spectrometry. This masterclass will demonstrate the use of the NIST (National Institute of Standards and Technology) software suite...

The Asia-Oceania Mass Spectrometry Conference (AOMSC), held from 5th-7th January 2020, Macau, is a conference collaboratively organized by the Mass Spectrometry societies in the Asia/Oceania region. The overall theme of the conference is “The Art...

Plasma Spectrochemistry for Trace Element, Stable Isotope, Elemental Imaging and Speciation Analyses.

The 2020 Winter Conference on Plasma Spectrochemistry, 21st in a series of biennial meetings, features developments in plasma spectrochemical...

This technical article describes how two new techniques have arisen which result in more complete fragmentation with better predictability for multiple-charge precursor ions. The techniques are electron capture dissociation (ECD) and electron...

We typically think of a mass spectrum as consisting of a precursor ion at high m/z and a series of increasingly lower m/z product (fragment) ions. These types of mass spectra are shown in training courses and textbooks as didactic examples because...

In this technical article the use of multiple-charge ions in protein and peptide analysis, such as the determination of intact protein molecular mass is discussed.

Structural Identification of Unknowns from Spectra Obtained Using LC/MS and CAD Techniques and EI Mass Spectral Database.

This installment in the series on NIST 11 (National Institute of Standards and Technology) is about the Incremental Name Search , replicate spectra, and the NIST GC Methods, and Retention Index Database.