Mass Spectrometry Blog

[eBook] LC-MS and MS Proteomics Methods and Workflows

Separation Science, in collaboration with Thermo Fisher Scientific, offers an eBook that focuses on LC-MS and MS proteomics methods and workflows.

Quality: The Third Side of the Analytical Success Triangle

As analytical chemists, we spend considerable time thinking about and working with basic scientific principles combined with the technology and products that allow us to solve our analytical problems. However, it is essential for success of any...

Importance of Limits Option in the NIST Mass Spectral Search Program

The Wiley Registry of Mass Spectral Data has contained a number of “single-peak” spectra such as those shown in Figure 1. Such spectra in an EI database used for the identification of unknowns based on their mass spectra are of no benefit. These...

Field Asymmetric Ion Mobility Spectrometry (FAIMS/DMS) Applications

This technical article is looking at the incorporation of FAIMS/DMS into a conventional LC/MS system to provide an added dimension of ion separation which is orthogonal to both chromatographic and mass spectrometric separation mechanisms. In a...

A Primer on Ion Mobility Spectrometry

Ion mobility spectrometry (IMS), by itself has found a niche in many areas including security screening, environmental monitoring, military applications, and analytical laboratory use. The technique is not mass spectrometry, however it is related...

Choose the Right Interface for LC/MS Success

Many analysts never consider anything beyond the electrospray interface for LC/MS. Electrospray is undeniably a very flexible technique. It works well for macromolecules as well as small molecules, positive and negative ion mode, and is a great...

FREE Master Class on LCMS Unknown Identification Using MSMS Libraries

MS/MS (Tandem) spectra can be used to identify unknowns employing library searches. This is accomplished in much the same approach as that employed for EI GC-MS with the NIST search software. The much improved NIST Search Version 2.4 is included...

FREE Master Class on Effective Use of Mass Spectral Databases

Mass spectral libraries are a powerful tool for the identification of organic compounds in complex mixtures by mass spectrometry. This masterclass will demonstrate the use of the NIST (National Institute of Standards and Technology) software...

Asia-Oceania Mass Spectrometry Conference 2020

The Asia-Oceania Mass Spectrometry Conference (AOMSC), held from 5th-7th January 2020, Macau, is a conference collaboratively organized by the Mass Spectrometry societies in the Asia/Oceania region. The overall theme of the conference is “The Art...

2020 Winter Conference on Plasma Spectrochemistry

Plasma Spectrochemistry for Trace Element, Stable Isotope, Elemental Imaging and Speciation Analyses.

The 2020 Winter Conference on Plasma Spectrochemistry, 21st in a series of biennial meetings, features developments in plasma spectrochemical...

Use of ECD and ETD Fragmentation Mechanisms for Peptide Sequencing

This technical article describes how two new techniques have arisen which result in more complete fragmentation with better predictability for multiple-charge precursor ions. The techniques are electron capture dissociation (ECD) and electron...

The Importance of Multiple-Charge Ion Precursors in Peptide MS/MS Sequencing

We typically think of a mass spectrum as consisting of a precursor ion at high m/z and a series of increasingly lower m/z product (fragment) ions. These types of mass spectra are shown in training courses and textbooks as didactic examples...

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