Mass Spectrometry

Minimization of the Required Sample Volume for Agilent RapidFire High-Throughput Mass Spectrometry System

This application note describes analysis with the Agilent RapidFire high-throughput MS system using tubing with a smaller inner diameter (id). This way, the necessary sample volume could be minimized.

Automated Method Development Using a High‑Throughput Mass Spectrometry System

This application note demonstrates a procedure for optimizing a method for a small example molecule, cyclic AMP. The final method has a CV of <3%, greatly improved peak shape, and 20-fold reduced carryover as compared to the generic starting method.

High-Throughput Direct Injection Analysis by Mass Spectrometry

Due to large numbers of samples and the associated analysis time for each, using mass spectrometry (MS) as a primary screening technique can be a long, tedious process. This application note presents a modified Agilent RapidFire high‑throughput MS...

[eBook] LC-MS and MS Proteomics Methods and Workflows

Separation Science, in collaboration with Thermo Fisher Scientific, offers an eBook that focuses on LC-MS and MS proteomics methods and workflows.

Field Asymmetric Ion Mobility Spectrometry (FAIMS/DMS) Applications

This technical article is looking at the incorporation of FAIMS/DMS into a conventional LC/MS system to provide an added dimension of ion separation which is orthogonal to both chromatographic and mass spectrometric separation mechanisms. In a...

Choose the Right Interface for LC/MS Success

Many analysts never consider anything beyond the electrospray interface for LC/MS. Electrospray is undeniably a very flexible technique. It works well for macromolecules as well as small molecules, positive and negative ion mode, and is a great...

FREE Master Class on LCMS Unknown Identification Using MSMS Libraries

MS/MS (Tandem) spectra can be used to identify unknowns employing library searches. This is accomplished in much the same approach as that employed for EI GC-MS with the NIST search software. The much improved NIST Search Version 2.4 is included...

FREE Master Class on Effective Use of Mass Spectral Databases

Mass spectral libraries are a powerful tool for the identification of organic compounds in complex mixtures by mass spectrometry. This masterclass will demonstrate the use of the NIST (National Institute of Standards and Technology) software suite...

Asia-Oceania Mass Spectrometry Conference 2020

The Asia-Oceania Mass Spectrometry Conference (AOMSC), held from 5th-7th January 2020, Macau, is a conference collaboratively organized by the Mass Spectrometry societies in the Asia/Oceania region. The overall theme of the conference is “The Art...

Adjusting electrospray voltage for optimum results

An electrospray LC/MS interface consists of an enclosed, atmospheric pressure chamber whereby the HPLC effluent enters this chamber through a capillary tube. This is surrounded by a second, concentric tube through which a nebulizing gas is applied....

Dealing with Metal Adduct Ions in Electrospray: Part 2

Previously we discussed the fundamental issue of metal adduct ion formation in electrospray LC/MS including method development strategies for dealing with adduct ions. This article will examine a real-world application which employs these...

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