Bioclinical Analysis

Effective procedure for in-well hydrolysis of urine samples

UCT has produced an application note outlining a suggested procedure for in-well hydrolysis of urine samples using the company's Refine™ Ultra-Filtration Technology. Using this technology reduces column backpressure while also reducing analyte...

Simultaneously analyse catecholamines and metanephrines in urine by LC-MS/MS

Restek has produced an application note introducing a simple solid-phase extraction procedure for the simultaneous analysis of catecholamines and metanephrines in urine that is suitable for high-throughput clinical diagnostics.

Reducing analyte suppression and HPLC column backpressure

UCT has produced an application note outlining a suggested procedure that reduces column backpressure while also reducing analyte suppression, when compared to a standard dilute and shoot protocol. Using UCT’s Refine™ Ultra-Filtration Technology...

Characterising cannabis extracts using flow-modulated GC×GC–TOF MS/FID

This study demonstrates the use of flow-modulated GC×GC to analyse complex cannabis extracts, with simultaneous detection by TOF MS for confident identification and FID for robust quantitation.

Absolute Quantification of Proteins in Snake Venom

Agilent Technologies has produced an application note describing the absolute quantification of snake venom proteins. Using capillary LC to separate the proteins, followed by sulfur determination using isotope dilution ICP-QQQ, accurate...

Effective Extraction of a Panel of Steroid Hormones from Human Serum

Biotage has produced an application note describing the extraction of a panel of steroid hormones from human serum using ISOLUTE® SLE+ Supported Liquid Extraction plates prior to LC/MS-MS analysis.

IC-ICP/MS analysis of iodised X-ray contrast media

The use of contrast media in non-invasive diagnostics facilitates targeted imaging of organs and distinction between healthy and unhealthy tissue. One differentiates between contrast media for magnetic resonance imaging (MRI) and X-ray...

Extraction of Oxytocin and Vasopressin from Serum using SPE Procedure Prior to LC-MS/MS

Biotage has produced an application note describing the extraction of the peptides oxytocin and vasopressin from serum using a fast, simple EVOLUTE EXPRESS load-wash-elute SPE procedure and achieving high reproducible extraction recoveries.

CESI-MS helps your charge heterogeneity analysis of mAbs

Looking for a new tool to characterize monoclonal antibodies at the intact level - if so, CESI-MS might be just what you're looking for...

Introduction to Pharmacology and Toxicology of Fentanyl and Fentanyl Analogs

Would you like to learn about fentanyl and designer opioids/fentanyl analogs via discussion of their pharmacology and toxicology? Do you need to discover an analytical method for the detection of these compounds in post-mortem human blood and...

How to Rapidly Identify Explosives and Other Substances of Forensic Interest

Do you need to gain an understanding of how explosive traces can be accurately detected in seconds without sample preparation? If so, this presentation will demonstrate a process involving the use of thermal desorption methods for rapid...

How to Optimize Existing Techniques to Enhance the Detection of New Psychoactive Substances in Biological Matrices

Would you like to improve your chances of detecting new psychoactive compounds (NPS) by applying different sample preparation techniques? If so, this presentation will show you how to make slight tweaks to existing methods to enhance the...

    

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