Bioclinical Analysis

How to analyse cysteine-linked ADC using HIC

In this application note from Agilent Technologies hydrophobic interaction chromatography (HIC) is used for the determination of the drug-to-antibody ratio (DAR) of a cysteine-linked antibody drug conjugate (ADC).

Analysis of Tryptic Digests of a mAb and an ADC with the Agilent 1290 Infinity II LC

Agilent Technologies has produced an application note describing the analysis of tryptic digests of the monoclonal antibody (mAb) trastuzumab, or trade name Herceptin, and the antibody-drug conjugate (ADC) ado-trastuzumab emtansine, or trade...

High-Throughput Dynamic Light Scattering Instrument with 21CFR11 Compliance

Wyatt Technology, a leader in instrumentation for absolute macromolecular and nanoparticle characterization, announces the release of its 21CFR11-compliant software for its groundbreaking DynaPro® Plate Reader II (PRII). The DynaPro PRII is said...

Extraction of Illicit Drugs and Pesticides from Liver Tissue Prior to GC-MS Analysis

Biotage has produced an application note describing the extraction of a broad range of analytes from liver tissue matrix prior to GC/MS analysis using ISOLUTE ® SLE+ supported liquid extraction columns. 

An Efficient Method to Analyse THC and THCCOOH in Oral Fluid using LC-MS/MS


Thermo Fisher Scientific has produced an application note describing a sensitive and simple LC-MS/MS method for quantitative analysis of THC and THCCOOH in oral fluid for forensic toxicology laboratories.


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