Bioclinical Analysis

Current Methods and Strategies for Biotherapeutic Impurity Profiling

The forum discussion will focus on impurity profiling in the development and manufacture of therapeutic proteins. Industry and regulatory experts will share their insights into the technologies and methods for developing an impurity control strategy.

Solutions for Oligonucleotide Drug Analysis

Separation Science, in collaboration with Shimadzu, offers a series of application notes providing solutions for oligonucleotide drug analysis. Click on the button below to download your personal copies.

Solutions for LC/MS Bioanalysis of Antibody Drugs

Separation Science, in collaboration with Shimadzu, offers a series of application notes providing solutions for LC/MS bioanalysis of antibody drugs. Click on the buttons below to download your personal copies.

Methods for mAb and ADC analysis

Separation Science, in collaboration with Agilent, has created an educational resource including application notes outlining methods for monoclonal antibody and antibody-drug conjugate analysis. Content in this valuable learning resource includes:

Quantification of immunosuppressants in human blood by liquid chromatography-tandem mass spectrometry

This technical note describes the implementation of an analytical method for the quantification of four immunosuppressants (tacrolimus, sirolimus, everolimus, and cyclosporine A) in human blood on a Thermo Scientific™ TSQ Quantis™ triple quadrupole...

Effective characterization of protein-nucleic acid interactions by light scattering

Would you like to discover an effective method for characterizing protein-nucleic acid interactions? Would you be interested in quantifying these interactions and gain a better understanding of how to control their biomolecular mechanisms? If so,...

Effectively separate and characterize complex (bio)macromolecular architectures

Do you need to to interpret and evaluate distributions of size and conformation in complex (bio)macromolecular systems? Would you like to characterize and understand complex polymers and nanostructures? If so, this presentation from Separation...

Extraction of Oxytocin and Vasopressin from Serum using SPE Procedure Prior to LC-MS/MS

Biotage has produced an application note describing the extraction of the peptides oxytocin and vasopressin from serum using a fast, simple EVOLUTE EXPRESS load-wash-elute SPE procedure and achieving high reproducible extraction recoveries.

Improve your biomolecule separations with different column modalities...

Do you analyse biomolecules? Looking for ways to improve the efficiency and quality of your separations. If so, this presentation is aimed at you...

Extraction of Plasma Catecholamines and Metanephrines using SPE Prior to LC-MS/MS Analysis

Biotage has produced an application note describing a mixed-mode weak cation exchange SPE protocol for extraction of three catecholamines and three metanephrine metabolites from plasma prior to LC-MS/MS detection.

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