Bioclinical Analysis

Rapid Update of Screening Methods for the Detection of New Psychoactive Substance Use 

In this presentation from a recent 'Advances in Forensics & Toxicology eSeminar' hosted by Separation Science in collaboration with Bruker, Bjorn Moosmann provides a convenient workflow for rapidly updating screening methods for the detection of...

How to analyse cysteine-linked ADC using HIC

In this application note from Agilent Technologies hydrophobic interaction chromatography (HIC) is used for the determination of the drug-to-antibody ratio (DAR) of a cysteine-linked antibody drug conjugate (ADC).

Simultaneously determine prescription and designer benzodiazepines in urine by SPE and LC-MS/MS

This application note from UCT details a suggested procedure for the simultaneous determination of prescription and designer benzodiazepines in urine by SPE and LC-MS/MS.

Comparison of sample preparation options for the extraction of a panel of endogenous steroids

This poster from Biotage compares sample preparation options for the extraction of a panel of endogenous steroids from serum.

A simple dilute-and-shoot method for the analysis of fentanyl and its analogues in human urine by LC-MS/MS

This application note from Restek presents a simple dilute-and-shoot method that provides a fast 3.5 minute analysis of fentanyl and related compounds (norfentanyl, acetyl fentanyl, alfentanil, butyryl fentanyl, carfentanil, remifentanil, and...

A fast analytical SFC/MS method for the separation of D- and L-amphetamine

This application note from Agilent Technologies shows the development of an SFC method for the chiral separation of D- and L-amphetamine and the analysis of an authentic whole blood sample.

Effective procedure for in-well hydrolysis of urine samples

UCT has produced an application note outlining a suggested procedure for in-well hydrolysis of urine samples using the company's Refine™ Ultra-Filtration Technology. Using this technology reduces column backpressure while also reducing analyte...

Simultaneously analyse catecholamines and metanephrines in urine by LC-MS/MS

Restek has produced an application note introducing a simple solid-phase extraction procedure for the simultaneous analysis of catecholamines and metanephrines in urine that is suitable for high-throughput clinical diagnostics.

Reducing analyte suppression and HPLC column backpressure

UCT has produced an application note outlining a suggested procedure that reduces column backpressure while also reducing analyte suppression, when compared to a standard dilute and shoot protocol. Using UCT’s Refine™ Ultra-Filtration Technology...

Characterising cannabis extracts using flow-modulated GC×GC–TOF MS/FID

This study demonstrates the use of flow-modulated GC×GC to analyse complex cannabis extracts, with simultaneous detection by TOF MS for confident identification and FID for robust quantitation.

Absolute Quantification of Proteins in Snake Venom

Agilent Technologies has produced an application note describing the absolute quantification of snake venom proteins. Using capillary LC to separate the proteins, followed by sulfur determination using isotope dilution ICP-QQQ, accurate...

Effective Extraction of a Panel of Steroid Hormones from Human Serum

Biotage has produced an application note describing the extraction of a panel of steroid hormones from human serum using ISOLUTE® SLE+ Supported Liquid Extraction plates prior to LC/MS-MS analysis.

     

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