Bioclinical Analysis

LC-MS analysis of thyroid hormones in human serum

Thyroid hormones play critical roles in the regulation of biological processes, such as growth, metabolism, protein synthesis, and brain development. Specifically, both 3,3’,5,5’-tetraiodo-L-thyronine (thyroxine or T4) and 3,3’,5-triiodo-L...

New perspectives and technology in pyrolysis GC-MS

Would you like to simplify method development for pyrolysis GC-MS? If so, this webinar outlines the benefits of a filament-based pyrolyzer that offers the advantages of both platinum filament and furnace-based designs simplifying method...

High Resolution Orbitrap MS for Detecting New Psychoactive Drugs

In this on-demand webinar, hosted by Separation Science in collaboration with Thermo Fisher Scientific, you can learn about two analytical methods for the determination of new psychoactive stimulants (NPS) in urine by liquid chromatography–high...

Discover new developments and advances in forensics and toxicology

Separation Science, in collaboration with its sponsors GERSTEL, SCIEX and UCT has developed its fifth online eSeminar focusing on advances in forensics and toxicology, which is now available to view on-demand. With a varied programme delivered by...

Rapid Update of Screening Methods for the Detection of New Psychoactive Substance Use 

In this presentation from a recent 'Advances in Forensics & Toxicology eSeminar' hosted by Separation Science in collaboration with Bruker, Bjorn Moosmann provides a convenient workflow for rapidly updating screening methods for the detection of...

How to analyse cysteine-linked ADC using HIC

In this application note from Agilent Technologies hydrophobic interaction chromatography (HIC) is used for the determination of the drug-to-antibody ratio (DAR) of a cysteine-linked antibody drug conjugate (ADC).

Simultaneously determine prescription and designer benzodiazepines in urine by SPE and LC-MS/MS

This application note from UCT details a suggested procedure for the simultaneous determination of prescription and designer benzodiazepines in urine by SPE and LC-MS/MS.

Comparison of sample preparation options for the extraction of a panel of endogenous steroids

This poster from Biotage compares sample preparation options for the extraction of a panel of endogenous steroids from serum.

A simple dilute-and-shoot method for the analysis of fentanyl and its analogues in human urine by LC-MS/MS

This application note from Restek presents a simple dilute-and-shoot method that provides a fast 3.5 minute analysis of fentanyl and related compounds (norfentanyl, acetyl fentanyl, alfentanil, butyryl fentanyl, carfentanil, remifentanil, and...

A fast analytical SFC/MS method for the separation of D- and L-amphetamine

This application note from Agilent Technologies shows the development of an SFC method for the chiral separation of D- and L-amphetamine and the analysis of an authentic whole blood sample.

Effective procedure for in-well hydrolysis of urine samples

UCT has produced an application note outlining a suggested procedure for in-well hydrolysis of urine samples using the company's Refine™ Ultra-Filtration Technology. Using this technology reduces column backpressure while also reducing analyte...

Simultaneously analyse catecholamines and metanephrines in urine by LC-MS/MS

Restek has produced an application note introducing a simple solid-phase extraction procedure for the simultaneous analysis of catecholamines and metanephrines in urine that is suitable for high-throughput clinical diagnostics.

     

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