Bioclinical Analysis

In this application note from Agilent Technologies hydrophobic interaction chromatography (HIC) is used for the determination of the drug-to-antibody ratio (DAR) of a cysteine-linked antibody drug conjugate (ADC).

This application note from UCT details a suggested procedure for the simultaneous determination of prescription and designer benzodiazepines in urine by SPE and LC-MS/MS.

This poster from Biotage compares sample preparation options for the extraction of a panel of endogenous steroids from serum.

This application note from Agilent Technologies shows the development of an SFC method for the chiral separation of D- and L-amphetamine and the analysis of an authentic whole blood sample.

UCT has produced an application note outlining a suggested procedure for in-well hydrolysis of urine samples using the company's Refine™ Ultra-Filtration Technology. Using this technology reduces column backpressure while also reducing analyte...

UCT has produced an application note outlining a suggested procedure that reduces column backpressure while also reducing analyte suppression, when compared to a standard dilute and shoot protocol. Using UCT’s Refine™ Ultra-Filtration Technology...

Biotage has produced an application note describing the extraction of the peptides oxytocin and vasopressin from serum using a fast, simple EVOLUTE EXPRESS load-wash-elute SPE procedure and achieving high reproducible extraction recoveries.

Markes International has produced an application note describing the analysis of ignitable liquid residues (ILRs) from fire debris, using static or dynamic headspace sampling onto sorbent tubes, in conjunction with thermal desorption–gas...

Agilent Technologies has produced an application note describing a study presenting a method for analysing primary amino acids in cell culture media that decreases sample preparation time and increases reproducibility.

Shimadzu has produced an application note demonstrating a successful system configuration for analysing highly-polar compounds in urine that are otherwise extremely challenging.

Agilent Technologies has produced an application note describing the use of the Agilent 1290 Infinity II 2D-LC solution in the comparison of an infliximab originator and candidate biosimilar.

Biotage has produced an application note describing a mixed-mode weak cation exchange SPE protocol for extraction of three catecholamines and three metanephrine metabolites from plasma prior to LC-MS/MS detection.