Bioclinical Analysis Blog

Achieve fast, accurate, and routine determination of blood alcohol concentration

This application note describes the rapid, automated, and accurate determination of blood alcohol concentration by headspace coupled to gas chromatography and flame ionization detection.

Facilitate your clinical research and forensic testing

Thermo Fisher Scientific offers a free 880-page handbook featuring technical notes, educational tools, and peer-reviewed references to help facilitate your clinical research and forensic testing.

Simple method for the detection of controlled substances in blood samples

This technical note from Thermo Fisher Scientific describes the detection of controlled substances in blood samples using the VeriSpray ion source with TSQ Altis MS for clinical research and forensic toxicology.

Perform quantitative analysis of benzodiazepines by QuEChERS and LC-MS/MS

This application from UCT describes an easy, fast, and effective method using QuEChERS for the quantitative analysis of benzodiazepines in whole blood.

Flow-modulated GC×GC–FID to streamline profiling of cannabis terpenes and terpenoids

This study from SepSolve demonstrates the use of flow-modulated GC×GC–FID to streamline profiling of cannabis terpenes and terpenoids. A key feature is the enhanced separation provided by GC×GC, which improves confidence in compound identity and...

Phospholipid Analysis for Four Types of Mouse Tissues using Triple Quadrupole LC-MS/MS with SimLipid

Shimadzu has produced an application note describing phospholipid analysis for four types of mouse tissues performed by precursor ion scan (PIS) or neutral loss scan (NLS) with a triple quadrupole mass spectrometer.

How to analyse cysteine-linked ADC using HIC

In this application note from Agilent Technologies hydrophobic interaction chromatography (HIC) is used for the determination of the drug-to-antibody ratio (DAR) of a cysteine-linked antibody drug conjugate (ADC).

Simultaneously determine prescription and designer benzodiazepines in urine by SPE and LC-MS/MS

This application note from UCT details a suggested procedure for the simultaneous determination of prescription and designer benzodiazepines in urine by SPE and LC-MS/MS.

Comparison of sample preparation options for the extraction of a panel of endogenous steroids

This poster from Biotage compares sample preparation options for the extraction of a panel of endogenous steroids from serum.

A fast analytical SFC/MS method for the separation of D- and L-amphetamine

This application note from Agilent Technologies shows the development of an SFC method for the chiral separation of D- and L-amphetamine and the analysis of an authentic whole blood sample.

Effective procedure for in-well hydrolysis of urine samples

UCT has produced an application note outlining a suggested procedure for in-well hydrolysis of urine samples using the company's Refine™ Ultra-Filtration Technology. Using this technology reduces column backpressure while also reducing analyte...

Reducing analyte suppression and HPLC column backpressure

UCT has produced an application note outlining a suggested procedure that reduces column backpressure while also reducing analyte suppression, when compared to a standard dilute and shoot protocol. Using UCT’s Refine™ Ultra-Filtration Technology...

    

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