Bioclinical Analysis Blog

Flow-modulated GC×GC–FID to streamline profiling of cannabis terpenes and terpenoids

This study from SepSolve demonstrates the use of flow-modulated GC×GC–FID to streamline profiling of cannabis terpenes and terpenoids. A key feature is the enhanced separation provided by GC×GC, which improves confidence in compound identity and...

Phospholipid Analysis for Four Types of Mouse Tissues using Triple Quadrupole LC-MS/MS with SimLipid

Shimadzu has produced an application note describing phospholipid analysis for four types of mouse tissues performed by precursor ion scan (PIS) or neutral loss scan (NLS) with a triple quadrupole mass spectrometer.

How to analyse cysteine-linked ADC using HIC

In this application note from Agilent Technologies hydrophobic interaction chromatography (HIC) is used for the determination of the drug-to-antibody ratio (DAR) of a cysteine-linked antibody drug conjugate (ADC).

Simultaneously determine prescription and designer benzodiazepines in urine by SPE and LC-MS/MS

This application note from UCT details a suggested procedure for the simultaneous determination of prescription and designer benzodiazepines in urine by SPE and LC-MS/MS.

Comparison of sample preparation options for the extraction of a panel of endogenous steroids

This poster from Biotage compares sample preparation options for the extraction of a panel of endogenous steroids from serum.

A fast analytical SFC/MS method for the separation of D- and L-amphetamine

This application note from Agilent Technologies shows the development of an SFC method for the chiral separation of D- and L-amphetamine and the analysis of an authentic whole blood sample.

Effective procedure for in-well hydrolysis of urine samples

UCT has produced an application note outlining a suggested procedure for in-well hydrolysis of urine samples using the company's Refine™ Ultra-Filtration Technology. Using this technology reduces column backpressure while also reducing analyte...

Reducing analyte suppression and HPLC column backpressure

UCT has produced an application note outlining a suggested procedure that reduces column backpressure while also reducing analyte suppression, when compared to a standard dilute and shoot protocol. Using UCT’s Refine™ Ultra-Filtration Technology...

Extraction of Oxytocin and Vasopressin from Serum using SPE Procedure Prior to LC-MS/MS

Biotage has produced an application note describing the extraction of the peptides oxytocin and vasopressin from serum using a fast, simple EVOLUTE EXPRESS load-wash-elute SPE procedure and achieving high reproducible extraction recoveries.

Rapid Forensic Analysis of Fire Debris using Headspace Sampling onto Sorbent Tubes with TD–GC–MS

Markes International has produced an application note describing the analysis of ignitable liquid residues (ILRs) from fire debris, using static or dynamic headspace sampling onto sorbent tubes, in conjunction with thermal desorption–gas...

How to Determine Amino Acid Composition of Cell Culture Media and Protein Hydrosylate Standard

Agilent Technologies has produced an application note describing a study presenting a method for analysing primary amino acids in cell culture media that decreases sample preparation time and increases reproducibility.

Screening Analysis of Highly Polar Doping Agents in Urine using 2DLC-MS/MS

Shimadzu has produced an application note demonstrating a successful system configuration for analysing highly-polar compounds in urine that are otherwise extremely challenging.

    

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