Mass Spectrometry

Are you working with ICP-MS and looking for guidance on application setups? Separation Science has collaborated with the experts at Agilent to provide a video tutorial series to help you boost your ICP-MS skills. In the second tutorial in the...

Looking to learn more about ICP-MS sample introduction? Separation Science, in collaboration with Agilent, offers a series of video tutorials to help you improve your skills in ICP-MS analysis. In the first tutorial in the series, presenter Gareth...

This application note describes analysis with the Agilent RapidFire high-throughput MS system using tubing with a smaller inner diameter (id). This way, the necessary sample volume could be minimized.

This application note demonstrates a procedure for optimizing a method for a small example molecule, cyclic AMP. The final method has a CV of <3%, greatly improved peak shape, and 20-fold reduced carryover as compared to the generic starting method.

Due to large numbers of samples and the associated analysis time for each, using mass spectrometry (MS) as a primary screening technique can be a long, tedious process. This application note presents a modified Agilent RapidFire high‑throughput MS...

This on-demand webinar demonstrates the capability of SCIEX OS software to perform data acquisition for legacy SCIEX Triple Quad instruments. If you're looking to turn your triple quad up to 11 find out how by registering below.

By viewing this on-demand webinar you will gain a basic understanding of using electron activated dissociation (EAD) in MS/MS analysis for structural elucidation of lipids and learn how EAD can distinguish structural isomers of various lipid classes...

Separation Science, in collaboration with Thermo Fisher Scientific, offers an eBook that focuses on LC-MS and MS proteomics methods and workflows.

As analytical chemists, we spend considerable time thinking about and working with basic scientific principles combined with the technology and products that allow us to solve our analytical problems. However, it is essential for success of any...

The Wiley Registry of Mass Spectral Data has contained a number of “single-peak” spectra such as those shown in Figure 1. Such spectra in an EI database used for the identification of unknowns based on their mass spectra are of no benefit. These...

This technical article is looking at the incorporation of FAIMS/DMS into a conventional LC/MS system to provide an added dimension of ion separation which is orthogonal to both chromatographic and mass spectrometric separation mechanisms. In a...

Ion mobility spectrometry (IMS), by itself has found a niche in many areas including security screening, environmental monitoring, military applications, and analytical laboratory use. The technique is not mass spectrometry, however it is related to...

Many analysts never consider anything beyond the electrospray interface for LC/MS. Electrospray is undeniably a very flexible technique. It works well for macromolecules as well as small molecules, positive and negative ion mode, and is a great...

MS/MS (Tandem) spectra can be used to identify unknowns employing library searches. This is accomplished in much the same approach as that employed for EI GC-MS with the NIST search software. The much improved NIST Search Version 2.4 is included...

Mass spectral libraries are a powerful tool for the identification of organic compounds in complex mixtures by mass spectrometry. This masterclass will demonstrate the use of the NIST (National Institute of Standards and Technology) software suite...