Gas Chromatography

There has been a recent surge in discussions amongst gas chromatographers about switching from helium to hydrogen for carrier gas. Most GC manufacturers, column suppliers, and suppliers of bottled gases and/or gas generators have been feeding the...

We previously talked about determining limit of detection (LOD) and limit of quantitation (LOQ). I mentioned that it is important to pay attention to the detector acquisition rate and amplifier settings (if they are adjustable) since these can...

This technical article addresses the issue of understanding the best way to obtain a limit of detection and quantification. The case discussed involves the quantification of an illicit drug using external calibration.

In this article I discuss the dichotomy between the often touted benefits of fast GC methods and the proportion of GC methods actually in use. Chromatographers should be aware that one of the two primary advantages of GC over HPLC is its speed (the...

Commercialization of technologies to produce faster temperature ramps in GC have been some of the few GC advances in recent decades. This article will take a look at the utility and ultimate areas of practical application for these technologies.

Is the analytical result you are reporting valid? Maybe the ones from yesterday or last week were, but will the ones from today also be? Will the results from your tray of 70 samples have to be thrown out and the analyses be run again? This month we...

In this article we discuss the merits and deficiencies of sandwich injection techniques.

In this article we discuss issues related to inlet and liner activity.

In this article we discuss the calibration technique of standard addition.

This technical article covers the internal standard method of GC calibration.

This technical article discusses general approaches to GC response calibration and focuses on the simplest; external calibration.

In this article we continue the previous discussion of ferrules used in gas chromatography.

In this article we cover the first part of an important and often neglected topic: ferrules.

Under discussion is one of the newer approaches to capillary column backflush: the uncoated pre-column configuration.

Continuing our discussion of the three configurations of capillary column backflush, we cover the coated pre-column configuration.