Gas Chromatography Blog

Inlet Liners – Part 3

In this article we continue our liner discussion with a focus on liner volume. One of the most important liner design variables is the internal volume. Larger internal volumes are preferred for general use because they minimize the chance of vapor...

Inlet Liners – Part 2

Here we continue the discussion of inlet liners with a focus on liner outer diameter. It is important to realize that correct liner choice is most critical for:

Inlet Liners – Part 1

Selecting an appropriate inlet liner from the myriad available liner choices is a daunting task, especially when there is little qualified technical information about what differentiates them in terms of actual performance. Here we start...

Activity and Decomposition

Although gas chromatography has many positive attributes as an analytical tool, its incompatibility with labile and active compounds is certainly one of its biggest weaknesses. Here we discuss evidence of sample decomposition and what we might do...

Split Sample Introduction – Part 2: Measuring Flows, Liner Choice

Continuing our saga of split sample introduction, here we discuss measuring gas flows and liner selection for split injections.

Split Sample Introduction – Part 1: Background and Split Ratio

Anyone who analyses samples by capillary gas chromatography has most likely used a split inlet. Although simple in concept, there are a few things to keep in mind to get the best analytical results possible.

Saturation of GC Detectors

I recently received a question relating to the saturation of GC detectors. The GC user was unsure of the causes of saturation, what effect saturation might have on analytical results, how to know when it is happening, and how to avoid it.

Hydrogen vs. Helium as Carrier Gas — Hot Discussions

There has been a recent surge in discussions amongst gas chromatographers about switching from helium to hydrogen for carrier gas. Most GC manufacturers, column suppliers, and suppliers of bottled gases and/or gas generators have been feeding the...

Pay Attention to Acquisition Rate and Detector Range

We previously talked about determining limit of detection (LOD) and limit of quantitation (LOQ). I mentioned that it is important to pay attention to the detector acquisition rate and amplifier settings (if they are adjustable) since these can...

How do I Determine Limits of Detection and Quantification?

I received this question from Ask the Doctor . “I am doing some research trying to quantify an illicit drug using external calibration and I was wondering if you could help me understand the best way I can obtain my limit of detection and...

Why Don’t More People do Fast GC?

In this article I discuss the dichotomy between the often touted benefits of fast GC methods and the proportion of GC methods actually in use.   Chromatographers should be aware that one of the two primary advantages of GC over HPLC is its speed...

Too Fast GC — What is Too Fast in GC?

Commercialization of technologies to produce faster temperature ramps in GC have been some of the few GC advances in recent decades. This article will take a look at the utility and ultimate areas of practical application for these technologies.

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