Gas Chromatography

Hydrogen vs. Helium as Carrier Gas — Hot Discussions

There has been a recent surge in discussions amongst gas chromatographers about switching from helium to hydrogen for carrier gas. Most GC manufacturers, column suppliers, and suppliers of bottled gases and/or gas generators have been feeding the...

Pay Attention to Acquisition Rate and Detector Range

We previously talked about determining limit of detection (LOD) and limit of quantitation (LOQ). I mentioned that it is important to pay attention to the detector acquisition rate and amplifier settings (if they are adjustable) since these can...

How do I Determine Limits of Detection and Quantification?

I received this question from Ask the Doctor . “I am doing some research trying to quantify an illicit drug using external calibration and I was wondering if you could help me understand the best way I can obtain my limit of detection and...

Why Don’t More People do Fast GC?

In this article I discuss the dichotomy between the often touted benefits of fast GC methods and the proportion of GC methods actually in use.   Chromatographers should be aware that one of the two primary advantages of GC over HPLC is its speed...

Too Fast GC — What is Too Fast in GC?

Commercialization of technologies to produce faster temperature ramps in GC have been some of the few GC advances in recent decades. This article will take a look at the utility and ultimate areas of practical application for these technologies.

Preventative GC maintenance and performance verification testing

Is the analytical result you are reporting valid? Maybe the ones from yesterday or last week were, but will the ones from today also be? Will the results from your tray of 70 samples have to be thrown out and the analyses be run again? This month...

Sandwich Injections

In this article we discuss the merits and deficiencies of sandwich injection techniques.

Inlet Activity

In this article we discuss issues related to inlet and liner activity.

Calibration Curves – Part 3, Standard Addition

In this article we discuss the calibration technique of standard addition.

Calibration Curves – Part 2, Internal Standard Approach

In this article we cover the internal standard method of GC calibration.

Calibration Curves – Part 1

In this article we discuss general approaches to GC response calibration and focus on the simplest; external calibration.

All About GC Ferrules – Part 2, Graphite and Polymeric Ferrules

In this article we continue the previous discussion of ferrules used in gas chromatography.

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