Mass Spectrometry

Previously we discussed the fundamental issue of metal adduct ion formation in electrospray LC/MS including method development strategies for dealing with adduct ions. This article will examine a real-world application which employs these...

In this technical article you will learn about the adduction of alkali metal ions (Na, K), to analyte molecules with the term “metal adduct ion” being used to refer to these species.

Reducing the internal diameter of your HPLC columns is an advantage for electrospray (ESI) LC/MS users. To understand this, two characteristics of ESI must be understood: (1) how response (i.e., peak area or height), is related to analyte...