Spectroscopy Solutions

Structural NMR Techniques Contribution to Late Lead Optimization & Preclinical Development

In this on-demand presentation, some examples of applications of different NMR structural techniques with cases from late lead optimization and preclinical development phase will be presented and discussed. Focus will be given also to the combined use of techniques to result in the full physical-chemical profile of the selected drug candidates.

 

As well known, analytical and structural are contributing to the entire drug discovery and development process with insights on the compounds structures and behaviours.


In the late optimization and preclinical phases, structural techniques’ contributions range from chemical reactions monitoring and identification of by-products and impurities, full identification and structure characterization, purity and stability, providing information also on in vitro/ex vivo/in vivo studies, with mechanism understanding and metabolites identification.


Some examples of application of different structural techniques with cases from late lead optimization and preclinical development phase will be presented and discussed.


Focus will be given also to the combined use of techniques to result in the full physical-chemical profile of the selected drug candidates.

 

Carla MarchioroCarla Marchioro is the Scientific Director, and Head of the Drug Discovery and Development Division at Research for Rent, R4R, Italy. Previously she covered related positions in Aptuit and GlaxoSmithKline R&D where she led multidisciplinary and cross national groups (with direct responsibility for over 50 scientists.

She is an NMR expert with great experience in structural techniques. Over the years, she has developed an extended experience in a large part of the Research & Development process from target identification and progression to NDA filling.

In addition to the R4R role, she is a member of a number of Scientific Boards, European and National Research funding bodies. She is the author of a number of publications and presentations and she is a well-recognized member in the scientific community. She has been a member of the ENC Scientific Board, the chair of the 51" ENC (2010), member of the SMASH Conference Board, and the chair of the SMASH 2013 Conference.

 

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