Pharmaceutical Analysis Blog

[eBook] GC Methods for Pharma & Clinical Analysis

Separation Science, in collaboration with Agilent, offers an eBook containing a selection of application notes relevant for pharmaceutical and clinical analysis using gas chromatography (GC). Discover an effective method for the analysis of USP<467> residual solvents, the determination of blood alcohol concentration or the analysis of impurities in sartan products. 

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The eBook contains the following applications:

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Analysis of USP <467> Residual Solvents
Analysis of residual solvent is a critical application in the pharmaceutical industry. USP 467 specifies a single column analysis with a secondary analysis in the case of detection above concentration limits. With the Agilent 7697A Headspace Sampler and an Agilent Intuvo 9000 GC configured with an inlet splitter, both analyses can be performed with a single system configured with dual columns and dual detectors.


Agilent Intuvo 9000 GC Analyzer for Blood Alcohol Concentration
Determination of blood alcohol concentration (BAC) requires rigorous control. While gas chromatographic systems configured with headspace samplers and flame ionization detection present the most straightforward analysis, the FID does not provide identification of the analytes. Determination and confirmation of BAC can be achieved on a single system with the Agilent Intuvo 9000 GC and Agilent 7697A Headspace Sampler.


Combined Analysis of N-Nitrosodimethylamine (NDMA) and N-Nitrosodiethylamine (NDEA) using the Agilent 7697A Headspace Sampler, 8890 GC System, and 5977 GC/MSD
This application note describes the use of the Agilent 8890 GC to analyze impurities in sartan products according to a United States Food and Drug Administration (US FDA) method. The workflow also features an Agilent 7697A headspace sampler and a 5977 GC/MSD. Results corresponded to expected detection values.

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