Fast and High-Resolution LC-MS Separation of PFAS

In this article from Issue 11 of the Analytix Reporter, produced by Merck, the rapid separation of 33 PFAS compounds as per EPA 537.1, EPA 533, and EPA 8327 is demonstrated.

PFAS (Per- and poly-fluoroalkyl substances) are persistent, man-made organic compounds, widely found in the environment. Recent awareness about their toxicity has led the U.S. Food and Drug Administration (FDA) and the U.S.
Environmental Protection Agency (EPA) to initiate actions against PFAS. Hence reliable and fast methods for their determination are needed.

PFASs are commonly measured using liquid chromatography–mass spectrometry (LC-MS). The column of choice for PFAS analysis by LC-MS(/MS) is a C18 column. The Ascentis^® Express PFAS columns are based on superficially porous silica particles (SPP) with C18 modification and are specifically tested using a PFAS compound mixture. This ensures the suitability and reliable performance of these columns for an efficient PFAS analysis.

LC-MS Analysis of PFAS - 33 Compounds in 5 minutes
The rapid separation of 33 PFAS compounds found in EPA 537.1, EPA 533, and EPA 8327 demonstrates that the Fused-Core^® technology of Ascentis^® Express PFAS HPLC columns benefits the PFAS analysis for fast, efficient, and rugged separations ― paramount to environmental analysis

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*The life science business of Merck operates as MilliporeSigma in the U.S. and Canada.