In this on-demand presentation, some examples of applications of different NMR structural techniques with cases from late lead optimization and preclinical development phase will be presented and discussed. Focus will be given also to the combined use of techniques to result in the full physical-chemical profile of the selected drug candidates.
Raman spectroscopy is an inelastic scattering technique that reveals vibrational spectra of molecules. When the excitation wavelength is tuned to fall within an absorption band of a chromophore, the Raman effect is called resonance Raman scattering.
[On-demand webinar] Vibrational spectroscopies constitute a diverse set of techniques that can provide valuable information about the structure and behaviour of any biological molecule under a wide range of experimental conditions. As such, the family of Raman and infrared spectroscopies are making significant impact in biology both for research and for applications in detection,...
Learn about accurate quantification of lipophilic toxins in shellfish and why it is important in food safety and often hampered due to lack or limited availability of authentic standards. To solve the problem, we investigated calibration of representative lipophilic shellfish toxin standards, DTX1, OA and YTX, by quantitative NMR (qNMR) using Certified Reference Material (CRM) as internal...
[On-demand webinar] Full-automated high resolution 1H-NMR spectroscopy offers unique screening capabilities for food quality and safety by combining non-targeted and targeted screening in one analysis (~ 20 minutes from acquisition to report). NMR reproducibility allows statistical investigations e.g. for detection of variety, geographical origin and adulterations, where smallest changes of...
Advion has produced an application note demonstrating how pure coconut oil is tested against a sample of coconut oil adulterated with canola oil for comparative data analysis offering a fast and easy method for purity analysis. The method uses the expressionL compact mass spectrometer (CMS) coupled with the Atmospheric Solids Analysis Probe (ASAP®) to determine and detect adulterants in...
[On-demand webinar] Molecular recognition by specific targets is at the heart of the life processes. In recent years, it has been shown that the interactions between proteins (lectins, enzymes, antibodies) and carbohydrates mediate a broad range of biological activities, from fertilization, embryogenesis, and tissue maturation, to pathological processes.
This on-demand webinar lecture by Apostolos Spyros will provide an overview of the different applications of liquid and solid state NMR in food analysis. You will learn about the broad array of analytical problems that can be tackled with NMR spectroscopy, including food authenticity, quality control and adulteration.
Coinciding with the celebration of its 50th anniversary of its presence in Europe this year, Shimadzu has released the UV-1900 UV-Vis spectrophotometer. Equipped with an ultrafast scan function that enables data acquisition of 29,000 nm/min (it takes about three seconds to measure in visible region), this spectrophotometer operates at one of the fastest rates in the industry.
Attend this on-demand webinar presented by Prof Jihad René Albani (Université des Sciences et Technologies de Lille, France) and through experimental examples you will discover the origin of fluorescence lifetimes of L-tryptophan free in solution and in peptides and proteins.
Attend this on-demand webinar by Carla Marchioro and you will learn how structural techniques contribute to drug discovery and development. This will be further explained through application examples.
Attend this on-demand webinar by Chris Lynch (PerkinElmer) and learn how do you decide the best match for the UV/Vis application being performed. There are a wide range of UV/Vis instruments on the market today with the capability to make water analysis measurements. So this is an important question that needs to be addressed, to make the correct selection to meet your needs now and in the...
