Separation Science

Identifying explosives and contraband vapours

Want to know how explosives and contraband vapour traces can be extracted and accurately detected without sample preparation and chromatography? Attend this educational presentation...

Trace detection equipment can be used in both the laboratory...

Cutting-edge mass spectrometry driving top-down proteomics

High-resolution and extreme-resolution mass spectrometry instrumentation is facilitating multidisciplinary research by the Ge lab, University of Wisconsin, a leader in the field of top-down proteomics. Read on to find out how...

New Tribrid Mass Spectrometer Delivers New Levels of Power and Performance for Protein and Small Molecule Characterization

Scientists facing highly complex characterization challenges can now gain a deeper understanding of their samples with new enhancements to the industry-leading Thermo Scientific Orbitrap Fusion Lumos Tribrid mass spectrometer that extend its...

Dealing with Metal Adduct Ions in Electrospray: Part 2

Previously we discussed the fundamental issue of metal adduct ion formation in electrospray LC/MS including method development strategies for dealing with adduct ions. This article will examine a real-world application which employs these...

Dealing with Metal Adduct Ions in Electrospray: Part 1

The term “adduct ion” is a popular term among liquid chromatography/mass spectrometry (LC/MS) users to describe ions formed by adduction of alkali metal ions to an analyte molecule in positive ion analysis. However, the well-informed user should...

Improving Electrospray LODs by Decreasing Column Diameter

Reducing the internal diameter of your HPLC columns is an advantage for electrospray (ESI) LC/MS users. To understand this, two characteristics of ESI must be understood: (1) how response (i.e., peak area or height), is related to analyte...