Separation Science

Cutting-edge mass spectrometry driving top-down proteomics

High-resolution and extreme-resolution mass spectrometry instrumentation is facilitating multidisciplinary research by the Ge lab, University of Wisconsin, a leader in the field of top-down proteomics. Read on to find out how...

New Tribrid Mass Spectrometer Delivers New Levels of Power and Performance for Protein and Small Molecule Characterization

Scientists facing highly complex characterization challenges can now gain a deeper understanding of their samples with new enhancements to the industry-leading Thermo Scientific Orbitrap Fusion Lumos Tribrid mass spectrometer that extend its...

Dealing with Metal Adduct Ions in Electrospray: Part 2

Previously we discussed the fundamental issue of metal adduct ion formation in electrospray LC/MS including method development strategies for dealing with adduct ions. This article will examine a real-world application which employs these...

Dealing with Metal Adduct Ions in Electrospray: Part 1

The term “adduct ion” is a popular term among liquid chromatography/mass spectrometry (LC/MS) users to describe ions formed by adduction of alkali metal ions to an analyte molecule in positive ion analysis. However, the well-informed user should...

Improving Electrospray LODs by Decreasing Column Diameter

Reducing the internal diameter of your HPLC columns is an advantage for electrospray (ESI) LC/MS users. To understand this, two characteristics of ESI must be understood: (1) how response (i.e., peak area or height), is related to analyte...

IC-MS for fast and robust analysis of pesticides in fruit and vegetables

Are you interested in a fast and easy, validated method for routine analysis of polar pesticidesand the benefits of using ion chromatography with HRAM mass spectrometry. If so, read on...

An MS technology to advance trace gas and headspace analysis

Selected ion flow tube mass spectrometry (SIFT-MS) can provide a significant advance in trace gas and headspace analysis. Direct, ultra-soft chemical ionization of volatile organic compounds (VOCs) and inorganic gases in air – coupled with mass...

     

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