Pharmaceutical Analysis Blog

Characterization of polymeric excipients with SEC and light scattering

Polymeric and other content can contribute up to 90% of the total mass in a pharmaceutical product, where excipients play a critical role in the drug’s performance. In just one example of the importance of excipient properties for therapeutic effect, the molar mass and degree of branching in polymeric excipients directly impact the rate of drug release.Separation Science, in collaboration with Wyatt Technology, offers an on-demand webinar that shows how conventional characterization techniques including size exclusion chromatography (SEC) and bulk viscosity measurements may fall short. The addition of light scattering analysis provides complete characterization of molar mass, viscosity, branching, conformation, conjugation, and size of excipients and other polymers.

AndrewMeyer
By viewing this presentation given by Andrew Meyer (Senior Applications Scientist, Wyatt Technology Corporation), you will learn...

  • Principles of MALS detection and calculation of polymer molecular size and mass
  • Identifying and overcoming shortfalls of conventional GPC/SEC
  • Leveraging DLS and viscosity for enhanced characterization of molecular size
  • Calculation of copolymer ratios and molecular weights in-line with SEC
  • Advantages of FFF for separation of branched polymers
    

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