In the first part of this series, an overview of the concept of method adjustment vs method change in reversed-phase HPLC is presented.
We all know that no HPLC method is perfect and that it may need to be “tweaked” once in a while to make it operate properly. But in today’s highly regulated environment, there’s always a question about whether or not such adjustments are allowed. For compendial methods in the pharmaceutical industry, the various pharmacopoeia give guidelines about method adjustment.
To view the full article complete the form below: