Desmopressin is a synthetic analogue of vasopressin, a natural pituitary hormone with antidiuretic properties. The deamination of vasopressin in the N-terminal 1 position and the replacement of 8-l-arginine with 8-d-arginine result in the formation of desmopressin. It has a longer duration of antidiuretic activity than that of the natural hormone and is essentially devoid of other associated pharmacological effects such as vasoconstriction and contraction of smooth muscles in the uterus or in the intestine.
This application note describes a successful micro LC-MS/MS method for the highly sensitive quantitation of desmopressin in human plasma. It shows how the QTRAP® 6500+ LC MS/MS system with OptiFlow™ Source coupled with a M5 MicroLC system provides reliable quantitation with high reproducibility, high throughput and minimum source optimization requirements.
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