Extractables and Leachables Analysis Using an Accurate Mass GC/Q-TOF

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The GC-amenable portion of E&L studies is conventionally carried out with a unit mass GC/MS in standard EI full scan mode, with compound identification through NIST GC/MS library searching. Limited knowledge can be obtained from this technique for those compounds detected without a convincing library match score. This work presents a novel tool to study E&L compounds with enhanced flexibility and confidence using a high-resolution accurate mass GC/Q-TOF equipped with a low-energy EI capable ion source.

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