This application note describes the application of SFC-MS/MS methods for bioanalysis of enantiomeric drugs, taking omeprazole and rabeprazole as examples.
Plasma matrix spiked with drugs were pretreated by a simple procedure without SPE and were analysed by isocratic flow of supercritical CO2 and methanol coupled to an LCMS-8050 mass spectrometer. The recovery rate was near 100% and good repeatability was demonstrated.
The results suggested that pharmacokinetic studies requiring chiral separation can be greatly facilitated by using SFC-MS/MS in terms of robustness, throughput and sensitivity.
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