Analysis of Fentanyl and Its Analogues in Human Urine by LC-MS/MS

Restek-fentanyl-and-its-analogues

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Synthetic opioid drugs, such as fentanyl and sufentanil, have very high analgesic potency. Abuse of these prescription painkillers — along with a rapidly growing list of illicit analogues — is a significant public health problem.

This application note presents a simple dilute-and-shoot method that provides a fast 3.5 minute analysis of fentanyl and related compounds (norfentanyl, acetyl fentanyl, alfentanil, butyryl fentanyl, carfentanil, remifentanil, and sufentanil) in human urine by LC-MS/MS using a Raptor Biphenyl column.

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