Monitoring post-translational modifications like oxidation during the development of monoclonal antibody (mAb) therapeutic is critical for the demonstration of product’s efficacy and/or stability. Subunit level analysis by LC-MS offers advantages by reducing the heterogeneity at the intact level. Moreover, this can be a method of choice over a conventional peptide mapping approach as this requires less sample preparation, reduces the chances of method artifacts and can be used for high throughput screening of mAb products during the development cycle. Learn more about how to monitor biotherapeutic oxidation levels in a simple and automated way using the X500B QTOF system and powerful BioPharmaView™ Software.
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