This application note describes an LC/MS/MS method for direct quantitation of artificial sweeteners in surface water and drinking water. Using the triple quadrupole system LCMS-8060 coupled with a biphenyl column, trace levels of artificial sweeteners in surface water could be detected without pre-treatment or enrichment. The ionization method was optimised in accordance to literature, allowing better fragmentation and sensitivity. Within a fast gradient elution of 6 minutes, the limit of detection of the method for ACE, CYC, SAC and ASP was better than 2.5 ng/L.
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