Characterization of Polymeric Excipients with Size Exclusion Chromatography and Light Scattering

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This webinar is now available in on-demand format. To register simply complete the form opposite:

Duration:
Approximately 70 minutes

The Presenter
AndrewMeyer.pngAndrew Meyer (Senior Applications Scientist, Wyatt Technology Corporation)

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Polymeric and other content can contribute up to 90% of the total mass in a pharmaceutical product, where excipients play a critical role in the drug’s performance.  In just one example of the importance of excipient properties for therapeutic effect, the molar mass and degree of branching in polymeric excipients directly impact the rate of drug release.

In this on-demand webinar we show how conventional characterization techniques including size exclusion chromatography (SEC) and bulk viscosity measurements may fall short. The addition of light scattering analysis provides complete characterization of molar mass, viscosity, branching, conformation, conjugation, and size of excipients and other polymers.

By viewing this on-demand presentation you will learn...

  • Principles of MALS detection and calculation of polymer molecular size and mass
  • Identifying and overcoming shortfalls of conventional GPC/SEC
  • Leveraging DLS and viscosity for enhanced characterization of molecular size
  • Calculation of copolymer ratios and molecular weights in-line with SEC
  • Advantages of FFF for separation of branched polymers

To register for this on-demand event complete the form opposite. By registering for this presentation you agree that the sponsor may provide you with additional materials related to the subject presented.