This application note describes the Nexera-UC online SFE-SFC system that was used for efficient analysis of alkylbenzenesulfone from a swab (cloth used for surface wiping to show safety at a pharmaceutical manufacturing site).
After systematic optimization for column selection and gradient conditions, the surfactant alkylbenzenesulfonate was detected with good peak shape and separation. The quantitation parameters for evaluation were obtained and they were satisfactory results.
The results demonstrated the simplicity and usefulness of the Nexera-UC system where supercritical fluid chromatography is used for both extraction and analysis.
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