Liver is the primary alternative tissue used for toxicological analysis based on the biological role it plays in the metabolism of drugs and toxicants in the body. While the benefits for analysing liver are clear, the one major drawback is the amount of sample preparation needed in order to get specimens ready for analysis.
This application outlines a modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) technique that has been optimized to extract common prescription and illicit drugs from liver prior to analysis by LC-MS/MS.
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