Biopharmaceutical Analysis Blog

Improve your bioprocessing applications for the purification of biomolecules

Tosoh Bioscience has produced Volume 1 of its 'Bioprocessing Application Notebook' that comprises over twenty application notes covering important aspects of biopharmaceutical purification.

Methods and applications in biopharmaceutical characterization eBook

Are you looking for solutions to your biopharmaceutical workflows? Struggling with your intact protein analysis, or need help with glycosylation studies? If so Separation Science, in collaboration with Thermo Fisher Scientific, has developed an...

How to analyse peptone samples using 2D–LC

This application from Agilent describes the 2D-LC analysis of complex peptones. Active solvent modulation proved to be valuable to maintain chromatographic performance and avoid breakthrough in the second dimension.

The importance of particle pore diameter for biomacromolecule separations

Recently, the evolution of middle to large biomacromolecules such as peptides or proteins is apparent in the market of pharmaceutical drugs in addition to traditional active ingredients based on small molecules. The use of peptides for clinical...

HPLC-DAD analysis of nucleotides

Phosphorylated compounds such as nucleotides are known to interact with stainless steel components leading to recovery issues in HPLC and LC/MS. Instrument and column inertness ensure successful analysis. Discover more about the bio-inert...

Download now the Bioanalysis Quantitation Applications eBook Vol 2

The therapeutic potential of biologic modalities has increased, driving an inevitable move toward exploring more complex biotherapeutic molecule classes. As biotherapeutics become more complex, there is still a demand for superior quantification...

Analysis of a bispecific monoclonal antibody with SEC-MS

Looking for an effective method for monoclonal antibody analysis? SEC-MS could be the answer...

The role of light scattering in biopharmaceutical formulation development

Are you involved in biopharmaceutical research? Would you like to find out more about the role of light scattering and associated techniques in characterizing biological molecules? This presentation from Separation Science, in collaboration with...

A biopharma collaboration - NIBRT and Thermo Fisher Scientific

Biopharmaceuticals represent protein molecules produced by genetically engineered living cells using large scale industrial bioprocessing. The complexity of these molecules requires advanced analytical characterisation strategies to ensure that...

Perform LCMS bioanalysis of antibody drugs using new nSMOL technology

This study describes the LCMS bioanalysis of antibody drugs using the Fab-selective proteolysis "nSMOL Method" offering an improvement of reaction conditions for automated analyses.

Comparing in-solution digestion approaches to quantify therapeutic mAb modifications

Do you work with therapeutic recombinant mAbs? Need to understand the extent of post-translational modifications? If so, you'll be interested in this comparison of in-solution protein digestion approaches...

The biopharma applications compendium

Are you looking for a comprehensive source of applications information for biopharmaceutical methods? If so, this biopharma applications compendium is what you need. Sign up to the Separation Science 'Biopharmaceutical Characterization Resource...

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