Biopharmaceutical Analysis Blog

A biopharma collaboration - NIBRT and Thermo Fisher Scientific

Biopharmaceuticals represent protein molecules produced by genetically engineered living cells using large scale industrial bioprocessing. The complexity of these molecules requires advanced analytical characterisation strategies to ensure that...

Get more information in less time: Improve your peptide mapping and PTM analysis skills

Peptide mapping is critical for characterizing protein drugs and monitoring product critical quality attributes (CQAs) in biopharma. Due to the heterogenous nature of protein drugs, comprehensive analytical characterization is required for...

Comparing in-solution digestion approaches to quantify therapeutic mAb modifications

Do you work with therapeutic recombinant mAbs? Need to understand the extent of post-translational modifications? If so, you'll be interested in this comparison of in-solution protein digestion approaches...

The biopharma applications compendium

Are you looking for a comprehensive source of applications information for biopharmaceutical methods? If so, this biopharma applications compendium is what you need. Sign up to the Separation Science 'Biopharmaceutical Characterization Resource...

Introducing the biopharmaceutical characterization resource center

Want to know more about biopharmaceutical characterization? Need help with your protein analysis or peptide mapping, require improved applications for glycan analysis or struggle with your chromatography or mass spectrometry? If so, this...

Essential applications for (U)HPLC analysis of biomolecules

Tosoh Bioscience has produced Volume 1 of its 'Biopharmaceutical Application Notebook' for the (U)HPLC analysis of biomolecules. This essential application notebook will keep you informed of all the latest developments in the biopharmaceutical...

Enabling single-software multiple attribute methodology for assessment of biopharmaceutical product quality attributes

This technical note from SCIEX will highlight how to implement a complete and easy-to-use Multiple Attribute Methodology (MAM) workflow for biotherapeutic PQA monitoring using accurate mass LC–MS. It will demonstrate how this new streamlined MAM...

[On-Demand Webinar] Accelerating Large Molecule LC-MS Method Development

Rapid development of sensitive and selective peptide bioanalytical methods are required to support the expanding protein component of pharmaceutical companies’ drug pipeline. Choosing the best MRM for a large molecule peptide or protein is a...

Biopharmaceutical Application Notebook for (U)HPLC Analysis of Biomolecules

Tosoh Bioscience has produced Volume 1 of its 'Biopharmaceutical Application Notebook' for the (U)HPLC analysis of biomolecules. This essential application notebook will keep you informed of all the latest developments in the biopharmaceutical...

HPAE-PAD - A very useful tool for glycan analysis

Looking for analytical advantage with your glycan and glycosylation analysis? If so, then high-performance anion-exchange chromatography with pulsed amperometric detection may well be worth a look...

Extractables and Leachables from Single Use Bioprocess Systems

Extractables and leachables (E&Ls) are small molecules present in a polymer system including antioxidants, surfactants, slip agents, plasticizers, acid scavengers, cross linking agents, residual monomers and oligomers, polymerization side...

Discover Single-Digit ppm Host Cell Proteins in Purified Antibody Samples

Recombinant biopharmaceutical proteins are expressed in host cell systems that contain numerous host cell proteins (HCPs). Even after a series of purifications, low levels of HCPs can remain in the purified biotherapeutics, which could reduce...

    

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