Bioclinical Analysis

CESI-MS helps your charge heterogeneity analysis of mAbs

Looking for a new tool to characterize monoclonal antibodies at the intact level - if so, CESI-MS might be just what you're looking for...

Corporate_Head_FINAL_6x.jpgIntegrating capillary electrophoresis (CE) and electrospray ionization (ESI) into one dynamic process, within the same device (CESI), simplifies coupling CE with MS. And this coupled technique, CESI-MS, can be used to characterize mAbs at the intact level. In fact, CESI-MS can be employed to characterize differences in the charge and glycosylation profiles of ezAbs from different manufacturers.

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Separation Science, in collaboration with SCIEX, offers an on-demand presentation describing how CESI-MS is used to characterize:

  • Charge profiles (Percent of basic, main and acidic variants)
  • Post translational modification
  • Glycosylation profiles
  • Differences in the charge and glycosylation profiles of mAbs from different manufacturers

 

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The presentation is given by Esme Candish, an Application Scientist with SCIEX. Esme's current work focuses on applying CE and CESI-MS for the analysis of proteins and post-translational modifications. In this presentation Esme will discuss:

  • monoclonal antibody therapeutics
  • current approaches to characterize charge heterogeneity
  • charge heterogeneity of intact mAbs using CESI-MS

If you're looking for a new or alternative analytical tool for analysing charge heterogeneity in intact monoclonal antibodies then click the button below to view the presentation.

Learn more about  CESI-MS >>

 

    

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